ReviewFrontiers in neural circuits2016
Local Field Potentials: Myths and Misunderstandings.
Review in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 2 of them syntheses that pooled it.
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Who cites it
162 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- A causal role for the posterior corpus callosum in bimanual coordination.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice.The Journal of physiology · 2026Article
- Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality.iScience · 2026Article
- In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression.PLoS computational biology · 2026Article
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- High-resolution Bayesian Virtual Epileptic Patient using neural field models.Network neuroscience (Cambridge, Mass.) · 2026Article
- A neuroscientific hypothesis on the physical nature of consciousness.Frontiers in human neuroscience · 2026Article
- Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex.Journal of neural engineering · 2025Article
- Synchrony, oscillations, and phase relationships in collective neuronal activity: A highly comparative overview of methods.PLoS computational biology · 2025Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
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- Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.Epilepsia · 2025Article
- Chronic intermittent alcohol yields sex-specific disruptions in cortical-striatal-limbic oscillations in rats.Alcohol, clinical & experimental research · 2025Article
- Layers of the monkey visual cortex are selectively modulated during electrical stimulation.PLoS biology · 2025Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confounding factors and technical limitations. By and large, the main factor defining the amplitude of LFPs is the geometry of the current sources, over and above the degree of synchronization or the properties of the media. As such, similar levels of activity may result in potentials that differ in several orders of magnitude in different populations. The geometry of these sources has been experimentally inaccessible until intracerebral high density recordings enabled the co-activating sources to be revealed. Without this information, it has proven difficult to interpret a century's worth of recordings that used temporal cues alone, such as event or spike related potentials and frequency bands. Meanwhile, a collection of biophysically ill-founded concepts have been considered legitimate, which can now be corrected in the light of recent advances. The relationship of LFPs to their sources is often counterintuitive. For instance, most LFP activity is not local but remote, it may be larger further from rather than close to the source, the polarity does not define its excitatory or inhibitory nature, and the amplitude may increase when source's activity is reduced. As technological developments foster the use of LFPs, the time is now ripe to raise awareness of the need to take into account spatial aspects of these signals and of the errors derived from neglecting to do so.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.