Evidence map›Paper›PMID 28018112›Full record

Trial reportWorld journal of gastroenterology2016

Influence of capsaicin infusion on secondary peristalsis in patients with gastroesophageal reflux disease.

Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chien-Lin Chen, Fabio Pace

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Gastroesophageal Reflux Disease].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Chih-Hsun YiChih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chien-Lin Chen, Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 97002, Taiwan.
Wei-Yi LeiChih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chien-Lin Chen, Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 97002, Taiwan.
Jui-Sheng HungChih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chien-Lin Chen, Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 97002, Taiwan.
Tso-Tsai LiuChih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chien-Lin Chen, Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 97002, Taiwan.
Chien-Lin ChenChih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chien-Lin Chen, Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 97002, Taiwan.
Fabio PaceChih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chien-Lin Chen, Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 97002, Taiwan.
Tzu Chi University · TWLuigi Sacco Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine whether capsaicin infusion could influence heartburn perception and secondary peristalsis in patients with gastroesophageal reflux disease (GERD).

methodsSecondary peristalsis was performed with slow and rapid mid-esophageal injections of air in 10 patients with GERD. In a first protocol, saline and capsaicin-containing red pepper sauce infusions were randomly performed, whereas 2 consecutive sessions of capsaicin-containing red pepper sauce infusions were performed in a second protocol. Tested solutions including 5 mL of red pepper sauce diluted with 15 mL of saline and 20 mL of 0.9% saline were infused into the mid-esophagus

resultsInfusion of capsaicin significantly increased heartburn perception in patients with GERD (

conclusionAcute esophageal exposure to capsaicin enhances heartburn sensation and promotes secondary peristalsis in gastroesophageal reflux disease, but repetitive capsaicin infusion reverses these effects.

Indexed as

AdultCapsaicinDouble-Blind MethodEsophagusFemaleGastroesophageal RefluxHeartburnHumansMaleManometryMiddle AgedPeristalsisSensory System AgentsYoung AdultCapsaicinSensory System AgentsCapsaicinEsophageal manometryEsophageal motilityGastroesophageal reflux diseaseSecondary peristalsis

Identifiers

PMID28018112
PMCPMC5143751
OpenAlexW2560065532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.