ReviewWorld journal of gastroenterology2016
Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota.
Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial.Nature communications · 2023Trial
- Trial
- Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- The interplay of gut microbiota and intestinal motility in gastrointestinal function.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025Review
- A review of recent developments in the imaging of disorders of gut-brain interaction.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025Review
- Microbiota-derived acetylcholine can promote gut motility inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- The voltage-gated sodium channel, para, limits Anopheles coluzzii vector competence in a microbiota dependent manner.Scientific reports · 2023Article
- Reprogramming the Human Gut Microbiome Reduces Dietary Energy Harvest.Research square · 2023Article
- Review
- The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders.Biomedicines · 2022Review
- Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives.Aging and disease · 2022Article
- TLR2 and TLR4 Modulate Mouse Ileal Motility by the Interaction with Muscarinic and Nicotinic Receptors.Cells · 2022Article
- The Pathology and Physiology of Ileostomy.Frontiers in nutrition · 2022Review
- The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis.Nutrients · 2021Review
- The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Gastrointestinal Transit Time, Glucose Homeostasis and Metabolic Health: Modulation by Dietary Fibers.Nutrients · 2018Review
- Gut Microbiota-Based Therapies for Irritable Bowel Syndrome.Clinical and translational gastroenterology · 2018Article
- Recent advances in understanding and managing diverticulitis.F1000Research · 2018Review
- Diabetes-induced mechanophysiological changes in the small intestine and colon.World journal of diabetes · 2017Review
- The Gastric Ganglion ofFrontiers in physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last few years, the importance of the resident intestinal microbiota in the pathogenesis of several gastro-intestinal diseases has been largely investigated. Growing evidence suggest that microbiota can influence gastro-intestinal motility. The current working hypothesis is that dysbiosis-driven mucosal alterations induce the production of several inflammatory/immune mediators which affect gut neuro-muscular functions. Besides these indirect mucosal-mediated effects, the present review highlights that recent evidence suggests that microbiota can directly affect enteric nerves and smooth muscle cells functions through its metabolic products or bacterial molecular components translocated from the intestinal lumen. Toll-like receptors, the bacterial recognition receptors, are expressed both on enteric nerves and smooth muscle and are emerging as potential mediators between microbiota and the enteric neuromuscular apparatus. Furthermore, the ongoing studies on probiotics support the hypothesis that the neuromuscular apparatus may represent a target of intervention, thus opening new physiopathological and therapeutic scenarios.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.