ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2017
Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis.
Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Analysis of the differentially expressed genes in the combs and testes of Qingyuan partridge roosters at different developmental stages.BMC genomics · 2024Article
- Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders.Molecular metabolism · 2022Review
- 1-Marine drugs · 2022Article
- Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown.Journal of lipid research · 2022Article
- Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Hypothyroidism Intensifies Both Canonic and theCells · 2021Article
- Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes.International journal of molecular sciences · 2021Article
- AGMO Inhibitor Reduces 3T3-L1 Adipogenesis.Cells · 2021Article
- Article
- Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism.Cellular and molecular life sciences : CMLS · 2020Article
- Plasmalogens, platelet-activating factor and beyond - Ether lipids in signaling and neurodegeneration.Neurobiology of disease · 2020Review
- Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte DysfunctionAntioxidants & redox signaling · 2019Article
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Peroxisomal regulation of redox homeostasis and adipocyte metabolism.Redox biology · 2019Review
- Pex11a deficiency causes dyslipidaemia and obesity in mice.Journal of cellular and molecular medicine · 2019Article
- Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission.The Journal of clinical investigation · 2019Article
- Structural and functional roles of ether lipids.Protein & cell · 2018Review
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The importance of peroxisomes for adipocyte function is poorly understood. Herein, we provide insights into the critical role of peroxin 16 (PEX16)-mediated peroxisome biogenesis in adipocyte development and lipid metabolism. Pex16 is highly expressed in adipose tissues and upregulated during adipogenesis of murine and human cells. We demonstrate that Pex16 is a target gene of the adipogenesis "master-regulator" PPARγ. Stable silencing of Pex16 in 3T3-L1 cells strongly reduced the number of peroxisomes while mitochondrial number was unaffected. Concomitantly, peroxisomal fatty acid (FA) oxidation was reduced, thereby causing accumulation of long- and very long-chain (polyunsaturated) FAs and reduction of odd-chain FAs. Further, Pex16-silencing decreased cellular oxygen consumption and increased FA release. Additionally, silencing of Pex16 impaired adipocyte differentiation, lipogenic and adipogenic marker gene expression, and cellular triglyceride stores. Addition of PPARγ agonist rosiglitazone and peroxisome-related lipid species to Pex16-silenced 3T3-L1 cells rescued adipogenesis. These data provide evidence that PEX16 is required for peroxisome biogenesis and highlights the relevance of peroxisomes for adipogenesis and adipocyte lipid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.