ArticleBehavioural brain research2017
The effects of neonatal amygdala or hippocampus lesions on adult social behavior.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Evaluation of registration-based vs. manual segmentation of rhesus macaque brain MRIs.Brain structure & function · 2024Article
- Understanding the heterogeneity of anxiety using a translational neuroscience approach.Cognitive, affective & behavioral neuroscience · 2024Review
- Recombinant SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Stimulate Release of Different Pro-Inflammatory Mediators via Activation of Distinct Receptors on Human Microglia Cells.Molecular neurobiology · 2023Article
- Structural plasticity in the entorhinal and perirhinal cortices following hippocampal lesions in rhesus monkeys.Hippocampus · 2023Article
- Reorganization in the macaque interoceptive-allostatic network following anterior cingulate cortex damage.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Differential responses toward conditioned and unconditioned stimuli, but decreased hypothalamic-pituitary-adrenal axis responsiveness in neonatal hippocampal lesioned monkeys.Developmental cognitive neuroscience · 2022Article
- Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection.eLife · 2022Article
- Astrogliosis in juvenile non-human primates 2 years after infant anaesthesia exposure.British journal of anaesthesia · 2021Article
- Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala.International journal of molecular sciences · 2021Article
- Multidimensional processing in the amygdala.Nature reviews. Neuroscience · 2020Review
- IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cortico-Hippocampal Computational Modeling Using Quantum Neural Networks to Simulate Classical Conditioning Paradigms.Brain sciences · 2020Article
- Emotional responses in monkeys differ depending on the stimulus type, sex, and neonatal amygdala lesion status.Behavioral neuroscience · 2020Article
- Bridging the species gap in translational research for neurodevelopmental disorders.Neurobiology of learning and memory · 2019Article
- IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Lesion Studies in Contemporary Neuroscience.Trends in cognitive sciences · 2019Review
- Mast Cells, Stress, Fear and Autism Spectrum Disorder.International journal of molecular sciences · 2019Review
- Early amygdala damage alters the way rhesus macaques process species-specific audio-visual vocalizations.Behavioral neuroscience · 2019Article
- Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques.Science translational medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The present report details the final phase of a longitudinal evaluation of the social behavior in a cohort of adult rhesus monkeys that received bilateral neurotoxic lesions of the amygdala or hippocampus, or sham operations at 2 weeks of age. Results were compared to previous studies in which adult animals received amygdala lesions and were tested in a similar fashion. Social testing with four novel interaction partners occurred when the animals were between 7 and 8 years of age. Experimental animals interacted with two male and two female partners in two conditions - one in which physical access was restricted (the constrained social access condition) and a second in which physical access was unrestricted (the unconstrained social access condition). Across conditions and interaction partners, there were no significant effects of lesion condition on the frequency or duration of social interactions. As a group, the hippocampus-lesioned animals generated the greatest number of communicative signals during the constrained social access condition. Amygdala-lesioned animals generated more frequent stress-related behaviors and were less exploratory. Amygdala and hippocampus-lesioned animals demonstrated greater numbers of stereotypies than control animals. Subtle, lesion-based differences in the sequencing of behaviors were observed. These findings suggest that alterations of adult social behavior are much less prominent when damage to the amygdala occurs early in life rather than in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.