Evidence map›Paper›PMID 28017803›Full record

ArticleJournal of chemical neuroanatomy2017

Ca

Uhna Sung, Francesca Binda, Valentina Savchenko, William A Owens, Lynette C Daws

Abstract read
In one paragraph

Article in Journal of chemical neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Uhna SungDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232-8548, United States. Electronic address: uhna.sung@gmail.com.
Francesca BindaInstitute of Cellular and Integrative Neurosciences, CNRS, Strasbourg, France.
Valentina SavchenkoDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232-8548, United States.
William A OwensDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, United States.
Lynette C DawsDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, United States. Electronic address: daws@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USVanderbilt University · USInstitut des Neurosciences Cellulaires et Intégratives · FR

Funding

NEUROTRANSMITTER TRANSPORTR01DA008213 · NIDA · YALE UNIVERSITY · PI RUDNICK, GARY W · 1993 to 2014
$3.5M
Mechanisms Regulating Serotonin Clearance In Vivo: Studies Using KO MiceR01MH064489 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAWS, LYNETTE C · 2002 to 2011
$3.0M
ACUTE REGULATION OF NOREPINEPHRINE TRANSPORTERSR01MH058921 · NIMH · VANDERBILT UNIVERSITY · PI GALLI, AURELIO · 1998 to 2008
$2.6M
Mechanisms regulating serotonin clearance in vivo: Studies using KO miceR56MH064489 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAWS, LYNETTE C · 2014 to 2014
$372k
A Proteomic Analysis of the Norepinephrine TransporterR21MH073662 · NIMH · YALE UNIVERSITY · PI SUNG, UHNA · 2006 to 2007
$344k
NIDA NIH HHS R01 DA008213NIMH NIH HHS R01 MH058921NIMH NIH HHS R01 MH064489NIMH NIH HHS R21 MH073662NIMH NIH HHS R56 MH064489
6 · The paper itself

Abstract

The antidepressant-sensitive norepinephrine (NE) transporter (NET) inactivates NE released during central and peripheral neuronal activity by transport into presynaptic cells. Altered NE clearance due to dysfunction of NET has been associated with the development of mental illness and cardiovascular diseases. NET activity in vivo is influenced by stress, neuronal activity, hormones and drugs. We investigated the mechanisms of Ca

Indexed as

AnimalsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCell LineMiceMice, Inbred C57BLNorepinephrine Plasma Membrane Transport ProteinsProtein TransportRatsRats, Sprague-DawleyThreonineCalcium-Calmodulin-Dependent Protein Kinase Type 2Norepinephrine Plasma Membrane Transport ProteinsThreonineBAPTA/AM (PubChem CID: 2293)BIM (PubChem CID: 2396)CalciumCalcium calmodulin kinase ICalcium calmodulin kinase IIDesipramine (PubChem CID: 2995)EGTA (PubChem CID: 6207)KN93 (PubChem CID: 5312122)NE clearanceNorepinephrine transporterPMSF (PubChem CID: 4784)STO609 (PubChem CID: 16760660)Thapsigargin (PubChem CID: 446378)TraffickingW7 (PubChem CID: 124887)

Identifiers

PMID28017803
PMCPMC5481502
OpenAlexW2565952316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.