Evidence map›Paper›PMID 28017778›Full record

ArticleBiochemical pharmacology2017

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G

F Chen, Y Wang, R Rafikov, S Haigh, W B Zhi, S Kumar, P T Doulias, O Rafikova, H Pillich, T Chakraborty and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

F ChenDepartment of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, China; Vascular Biology Center, Augusta University, Augusta, Georgia 30912, USA. Electronic address: fchen@njmu.edu.cn.
Y WangVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA.
R RafikovVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA.
S HaighVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA.
W B ZhiCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, Georgia 30912, USA.
S KumarVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA.
P T DouliasDepartment of Pediatrics, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.
O RafikovaVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA.
H PillichInstitute for Medical Microbiology, Justus Liebig University, Germany.
T ChakrabortyInstitute for Medical Microbiology, Justus Liebig University, Germany.
R LucasVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA; Department of Pharmacology, Augusta University, Augusta, Georgia 30912, USA.
A D VerinVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA.
J D CatravasOld Dominion University, Norfolk, VA, USA.
J X SheCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, Georgia 30912, USA.
S M BlackVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA.
D J R FultonVascular Biology Center, Augusta University, Augusta, Georgia 30912, USA; Department of Pharmacology, Augusta University, Augusta, Georgia 30912, USA. Electronic address: dfulton@augusta.edu.
Augusta University Health · USUniversity of Giessen · DEAugusta University · USChildren's Hospital of Philadelphia · USOld Dominion University · US

Funding

Protein Chemistry & Biophysics CoreP01HL134610 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M · 2018 to 2022
$11.6M
Therapeutic Mechanisms of RhoA Inhibition In Acute Lung InjuryP01HL101902 · NHLBI · AUGUSTA UNIVERSITY · PI BLACK, STEPHEN M · 2011 to 2016
$11.2M
PERINATAL REGULATION OF THE ENDOTHELIAL NOS GENER01HL060190 · NHLBI · UNIVERSITY OF MONTANA · PI Stephen M Black · 1998 to 2026
$7.1M
ROS in Pulmonary Hypertension: Role of ADMAR01HL067841 · NHLBI · UNIVERSITY OF MONTANA · PI BLACK, STEPHEN M · 2002 to 2011
$2.6M
Metabolic Determinants of Cardiovascular Dysfunction in ObesityR01HL092446 · NHLBI · AUGUSTA UNIVERSITY · PI FULTON, DAVID J, STEPP, DAVID W · 2009 to 2013
$2.1M
NHLBI NIH HHS P01 HL101902NHLBI NIH HHS P01 HL134610NHLBI NIH HHS R01 HL060190NHLBI NIH HHS R01 HL067841NHLBI NIH HHS R01 HL092446
6 · The paper itself

Abstract

Disruption of the endothelial barrier in response to Gram positive (G

Indexed as

AnimalsBacterial ToxinsCalciumChlorocebus aethiopsCOS CellsEndothelial CellsEndothelium, VascularHeat-Shock ProteinsHEK293 CellsHemolysin ProteinsHumansLungMicrovesselsMutationNitric OxideNitric Oxide DonorsBacterial ToxinsCalciumHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesNitric OxideNitric Oxide DonorsNitroso CompoundsrhoA GTP-Binding ProteinEndothelialG(+)-toxinsNitric oxidePermeabilityRhoAS-nitrosylation

Identifiers

PMID28017778
PMCPMC5768143
OpenAlexW2566273359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.