ArticleJournal of molecular and cellular cardiology2017
Selective coupling of the S1P
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In one paragraph
Article in Journal of molecular and cellular cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed.
- Endothelial S1PR3 downregulation exacerbates pressure overload-induced cardiac remodeling by promoting fibrosis and inflammation.Science China. Life sciences · 2026Article
- Lysophosphatidic acid-mediated NF-κB activation promotes FOXC2 expression essential for lymphatic valve development.The Journal of clinical investigation · 2026Article
- RhoA allosterically activates phospholipase Cε via its EF hands.Communications biology · 2025Article
- Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling.JACC. Basic to translational science · 2025Article
- The sphingosine-1-phosphate signaling pathway (sphingosine-1-phosphate and its receptor, sphingosine kinase) and epilepsy.Epilepsia open · 2025Review
- Untangling the role of RhoA in the heart: protective effect and mechanism.Cell death & disease · 2024Review
- Spatiotemporal sphingosine-1-phosphate receptor 3 expression within the cerebral vasculature after ischemic stroke.iScience · 2024Article
- High-Density Lipoprotein Signaling via Sphingosine-1-Phosphate Receptors Safeguards Spontaneously Hypertensive Rats against Myocardial Ischemia/Reperfusion Injury.Pharmaceutics · 2024Article
- Sphingosine-1-phosphate levels are inversely associated with left ventricular and atrial chamber volume and cardiac mass in men : The Study of Health in Pomerania (SHIP).Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases.Biomolecules · 2023Review
- Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a GCardiovascular drugs and therapy · 2023Article
- Role of G-protein coupled receptors in cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Review
- Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease.Journal of cardiovascular development and disease · 2022Review
- RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria.Cell death and differentiation · 2022Article
- Sphingolipid metabolism and signaling in cardiovascular diseases.Frontiers in cardiovascular medicine · 2022Review
- GαFrontiers in cell and developmental biology · 2022Review
- Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS.Computational and mathematical methods in medicine · 2022Article
- Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis.Drug design, development and therapy · 2022Article
- Review
- The role of sphingosine 1-phosphate and its receptors in cardiovascular diseases.Journal of cellular and molecular medicine · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Bryan S YungDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
Cameron S BrandDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
Sunny Y XiangDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
Charles B B GrayDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
Christopher K MeansGrifols Inc., Los Angeles, CA 90032, United States.
Hugh RosenDepartment of Chemical Physiology, Scripps Research Institute, La Jolla, CA 92037, United States.
Jerold ChunDepartment of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, Scripps Research Institute, La Jolla, CA 92037, United States.
Nicole H PurcellDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
Joan Heller BrownDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: jhbrown@ucsd.edu.
Shigeki MiyamotoDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: smiyamoto@ucsd.edu.
Funding
Surgery, Physiology and ImmunohistopathologyP01HL085577 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI GLEMBOTSKI, CHRIS · 2006 to 2017
$18.4MGRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5MTraining In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MRhoA mediated survival signals in cardiomyocytesR37HL028143 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER · 2010 to 2019
$4.0MRole of PHLPP in the HeartR01HL114949 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PURCELL, NICOLE H · 2014 to 2022
$3.7MTHROMBIN, GALPHA12, AND RHO AND CELL GROWTHR01GM036927 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER · 1986 to 2012
$3.4MS1P, Rho and Akt signaling in cardiomyocyte survivalR01HL028143 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER · 1985 to 2009
$2.7MOptimization of S1P3 antagonists for fibrotic diseaseR01AR069877 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ROSEN, HUGH · 2016 to 2018
$1.8MHexokinase-II protects the heart against ischemia through regulation of autophagyR56HL097037 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MIYAMOTO, SHIGEKI · 2015 to 2015
$388kRho- and GPCR-mediated signaling through novel cellular effectorsR56GM036927 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER · 2008 to 2008
$302kNHLBI NIH HHS P01 HL085577NHLBI NIH HHS R01 HL028143NHLBI NIH HHS R01 HL114949NHLBI NIH HHS R37 HL028143NHLBI NIH HHS R56 HL097037NHLBI NIH HHS T32 HL007444NIAMS NIH HHS R01 AR069877NIGMS NIH HHS R01 GM036927NIGMS NIH HHS R56 GM036927NIGMS NIH HHS T32 GM007752
Abstract
Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, is generated and released at sites of tissue injury in the heart and can act on S1P
Indexed as
AnimalsCardiomegalyLysophospholipidsMaleMiceMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacProprotein ConvertasesProtein BindingRatsReceptors, LysosphingolipidrhoA GTP-Binding ProteinSerine EndopeptidasesSignal TransductionSphingosineLysophospholipidsmembrane-bound transcription factor peptidase, site 1Proprotein ConvertasesReceptors, LysosphingolipidrhoA GTP-Binding ProteinSerine EndopeptidasesSphingosinesphingosine 1-phosphateTRPP Cation ChannelsCardioprotectionG protein-coupled receptor (GPCR)Ischemia/reperfusion (I/R)Phospholipase C (PLC)Protein kinase D (PKD)Ras homolog gene family member A (RhoA)Sphingosine-1-phosphate (S1P)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.