ArticleCancer cell2017
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N
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Article in Cancer cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 932 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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932citing papers in PubMed, 1 pooled it
44.7field-weighted citation impact, top 1% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
932 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,607 citations in OpenAlex.
- The relationship between the network of non-coding RNAs-molecular targets and N6-methyladenosine modification in tumors of urinary system.Cell death & disease · 2024Pooled it
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- Resolving challenges in detection and quantification of D-2-hydroxyglutarate and L-2-hydroxyglutarate via LC/MS.Methods (San Diego, Calif.) · 2026Article
- Cell-cycle-driven noncanonical ubiquitination of METTL14 orchestrates RNA methylation.Nature chemical biology · 2026Article
- RNA methylation as a leukemia stem cell vulnerability.Haematologica · 2026Article
- Targeting the SETD2-FTO-KIT pathway as a pharmacological strategy for TKI-refractory GIST.Acta pharmaceutica Sinica. B · 2026Article
- Synthesis and Binding Affinity Insights of 2-Phenyl-1H-Benzimidazole Inhibitors Targeting FTO by Spectroscopic Characterization and Molecular Docking.Journal of molecular recognition : JMR · 2026Article
- FTO-Driven m6A Demethylation of TNC Promotes Epithelial-Mesenchymal Transition and Gastric Cancer Metastasis.Biomedicines · 2026Article
- RNA modifications as determinants of cancer cell death: from epitranscriptomic mechanisms to therapeutic targeting.Functional & integrative genomics · 2026Review
- PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia.Leukemia · 2026Article
- Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants.Nature genetics · 2026Article
- Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis.Journal of intensive care · 2026Article
- Review
- Interplay between N6-methyladenosine RNA methylation and protein lactylation: a novel crosstalk linking metabolism and epigenetic regulation in human diseases.Journal of translational medicine · 2026Review
- A targetable FTO/SLC7A11/CBS/CTH axis controls cysteine metabolism, growth and survival in NSCLC.Science advances · 2026Article
- Chromosomal rearrangement-enhanced mRNA stability drives the oncogenic potential of fusion genes in pediatric leukemia.Haematologica · 2026Article
- Fat Mass and Obesity-Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B-Cell Lymphoma by Suppressing N6-Methyladenosine Methylation of Myc.The Kaohsiung journal of medical sciences · 2026Article
- Epigenetic Dysregulation of the Wnt/β-Catenin Pathway via FTO-m6A in the mPFC Contributes to Autism-Like Behaviors.Molecular neurobiology · 2026Article
- Strand displacement-driven dual-nuclease cascade strategy for preamplification-free and site-specific RNA m⁶A detection.Analytical and bioanalytical chemistry · 2026Article
872 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 6 institutions in 2 countries.
Zejuan LiSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Hengyou WengSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Rui SuDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Xiaocheng WengDepartments of Chemistry, Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA; College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Hubei, Wuhan 430072, PR China.
Zhixiang ZuoSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Chenying LiDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA; Key Laboratory of Hematopoietic Malignancies, Department of Hematology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, China.
Huilin HuangDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Sigrid NachtergaeleDepartments of Chemistry, Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
Lei DongDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Chao HuSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA; Key Laboratory of Hematopoietic Malignancies, Department of Hematology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, China.
Xi QinDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Lichun TangDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
Yungui WangSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA; Key Laboratory of Hematopoietic Malignancies, Department of Hematology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, China.
Gia-Ming HongSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Hao HuangSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Xiao WangDepartments of Chemistry, Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
Ping ChenSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Sandeep GurbuxaniDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
Stephen ArnovitzSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Yuanyuan LiSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Shenglai LiSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Jennifer StrongDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Mary Beth NeillySection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Richard A LarsonSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Xi JiangSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
Pumin ZhangDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
Jie JinKey Laboratory of Hematopoietic Malignancies, Department of Hematology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, China.
Chuan HeDepartments of Chemistry, Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.
Jianjun ChenSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA. Electronic address: chen3jj@ucmail.uc.edu.
University of Chicago · USUniversity of Cincinnati Medical Center · USFirst Affiliated Hospital Zhejiang University · CNBaylor College of Medicine · USHoward Hughes Medical Institute · USSun Yat-sen University · CN
Funding
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5MDirect Oxidative Nucleic Acids DemethylationR01GM071440 · NIGMS · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2005 to 2018
$3.7MSpindle Assembly Checkpoint, Chromosome Stability, and CancerR01CA122623 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2008 to 2016
$2.8MThe Function of Cdc14B in DNA Damage Repair and TumorigenesisR01CA116097 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2006 to 2015
$2.6MTargeting TET1 signaling to treat acute myeloid leukemiaR01CA211614 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.3MThe role and mechanism of FTO in leukemogenesis and drug responseR01CA214965 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.1MPotential therapeutic implications of targeting miR-150 in acute myeloid leukemiaR01CA182528 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2014 to 2018
$1.7MThe role and functional mechanism of TET1 in MLL-rearranged leukemiaR01CA178454 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2014 to 2018
$1.7MHoward Hughes Medical InstituteNCI NIH HHS R01 CA116097NCI NIH HHS R01 CA122623NCI NIH HHS R01 CA178454NCI NIH HHS R01 CA182528NCI NIH HHS R01 CA211614NCI NIH HHS R01 CA214965NCI NIH HHS T32 CA009594NIGMS NIH HHS R01 GM071440
Abstract
N
Indexed as
AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOApoptosisCell ProliferationHumansLeukemia, Myeloid, AcuteMethylationNucleophosminRetinoic Acid Receptor alphaSuppressor of Cytokine Signaling ProteinsTranscriptomeTretinoinAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOASB2 protein, humanFTO protein, humanN-methyladenosineNPM1 protein, humanNucleophosminRARA protein, humanRetinoic Acid Receptor alphaSuppressor of Cytokine Signaling ProteinsTretinoinAMLASB2ATRAcell differentiationFTOleukemogenesism6ARARARNA modificationRNA stability
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.