ArticleCurrent biology : CB2017
An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.Nature neuroscience · 2026Article
- Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics.Frontiers in psychiatry · 2026Review
- Article
- Prenatal diagnosis, ultrasound findings, and pregnancy outcome of 17q12 deletion and duplication syndromes: a retrospective case series.Archives of gynecology and obstetrics · 2024Article
- The physiological role of TRP channels in sleep and circadian rhythm.Journal of cellular and molecular medicine · 2024Review
- Tob Regulates the Timing of Sleep Onset at Night inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Evo-devo applied to sleep research: an approach whose time has come.Sleep advances : a journal of the Sleep Research Society · 2024Review
- Genome-wide epigenetic modifications in sports horses during training as an adaptation phenomenon.Scientific reports · 2023Article
- Exposure to war and conflict: The individual and inherited epigenetic effects on health, with a focus on post-traumatic stress disorder.Frontiers in epidemiology · 2023Review
- Article
- Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light.Frontiers in physiology · 2022Article
- Characterization of mWake expression in the murine brain.The Journal of comparative neurology · 2021Article
- Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons.Communications biology · 2021Article
- Using Circadian Rhythm Patterns of Continuous Core Body Temperature to Improve Fertility and Pregnancy Planning.Journal of circadian rhythms · 2020Review
- PhenomeXcan: Mapping the genome to the phenome through the transcriptome.Science advances · 2020Article
- The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.Nature communications · 2020Article
- Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus.Nature communications · 2020Article
- Circuit development in the master clock network of mammals.The European journal of neuroscience · 2020Review
- Distinct ipRGC subpopulations mediate light's acute and circadian effects on body temperature and sleep.eLife · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
The suprachiasmatic nucleus (SCN) is the central circadian clock in mammals. It is entrained by light but resistant to temperature shifts that entrain peripheral clocks [1-5]. The SCN expresses many functionally important neuropeptides, including vasoactive intestinal peptide (VIP), which drives light entrainment, synchrony, and amplitude of SCN cellular clocks and organizes circadian behavior [5-16]. The transcription factor LHX1 drives SCN Vip expression, and cellular desynchrony in Lhx1-deficient SCN largely results from Vip loss [17, 18]. LHX1 regulates many genes other than Vip, yet activity rhythms in Lhx1-deficient mice are similar to Vip
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.