Evidence map›Paper›PMID 28017513›Full record

ReviewTrends in microbiology2017

From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis.

Allison N Norsworthy, Melanie M Pearson

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 113 citations in OpenAlex.

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  19. Unveiling the hidden arsenal: new insights intoFrontiers in cellular and infection microbiology · 2024
    Review
  20. Overview ofFrontiers in microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Allison N NorsworthyDepartment of Microbiology, New York University Medical Center, New York, NY, USA.
Melanie M PearsonDepartment of Microbiology, New York University Medical Center, New York, NY, USA; Department of Urology, New York University Medical Center, New York, NY, USA; Current address: University of Michigan Medical School, Department of Microbiology and Immunology, 5641 Medical Science Building II, 1150 West Medical Center Dr., Ann Arbor, MI 48109-0620, USA. Electronic address: mpears@umich.edu.
Columbia University Irving Medical Center · USUniversity of Michigan–Ann Arbor · US

Funding

Uroplakins and Baterial InfectionP01DK052206 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SUN, TUNG-TIEN · 1999 to 2015
$19.6M
NIDDK NIH HHS P01 DK052206
6 · The paper itself

Abstract

Proteus mirabilis is a model organism for urease-producing uropathogens. These diverse bacteria cause infection stones in the urinary tract and form crystalline biofilms on indwelling urinary catheters, frequently leading to polymicrobial infection. Recent work has elucidated how P. mirabilis causes all of these disease states. Particularly exciting is the discovery that this bacterium forms large clusters in the bladder lumen that are sites for stone formation. These clusters, and other steps of infection, require two virulence factors in particular: urease and MR/P fimbriae. Highlighting the importance of MR/P fimbriae is the cotranscribed regulator, MrpJ, which globally controls virulence. Overall, P. mirabilis exhibits an extraordinary lifestyle, and further probing will answer exciting basic microbiological and clinically relevant questions.

Indexed as

Bacterial ProteinsBiofilmsCatheter-Related InfectionsFimbriae, BacterialHumansKidney CalculiProteus InfectionsProteus mirabilisRepressor ProteinsUreaseUrinary BladderUrinary Tract InfectionsBacterial ProteinsMrpJ protein, Proteus mirabilisRepressor ProteinsUreaseCAUTIcrystalline biofilmsfimbriaepolymicrobial infectionsProteus mirabilisureaseurinary stones

Identifiers

PMID28017513
PMCPMC5365347
OpenAlexW2563724458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.