ArticleJACC. Heart failure2017
Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study.
Article in JACC. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Aerobic Training Attenuates Differences Between Black and White Adults in Left Ventricular-Vascular Coupling and Wasted Pressure Effort.Journal of the American Heart Association · 2024Trial
- Ethnic cardiovascular disparities and lipidomic signatures in Chinese children: insights from a historical national survey and a contemporary regional cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
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- Predictors of Mortality in Acute Myocardial Infarction Patients With Systemic Lupus Erythematosus.Cureus · 2025Article
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- Distinguishing hypertensive cardiomyopathy from cardiac amyloidosis in hypertensive patients with heart failure: a CMR study with histological confirmation.The international journal of cardiovascular imaging · 2024Article
- Clinical, Echocardiographic, and Longitudinal Characteristics Associated With Heart Failure With Improved Ejection Fraction.The American journal of cardiology · 2024Article
- Subclinical Risk Factors for Heart Failure With Preserved and Reduced Ejection Fraction Among Black Adults.JAMA network open · 2022Article
- Racial Differences in Val122Ile-Associated Transthyretin Cardiac Amyloidosis.Journal of cardiac failure · 2022Article
- Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Posture-Related Differences in Cardiovascular Function Between Young Men and Women: Study of Noninvasive Hemodynamics in Rural Malawi.Journal of the American Heart Association · 2022Article
- Association between race and maladaptive concentric left ventricular hypertrophy in American-style football athletes.British journal of sports medicine · 2022Article
- Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling in the Community.Current cardiology reports · 2021Review
- Epidemiology of Heart Failure Stages in Middle-Aged Black People in the Community: Prevalence and Prognosis in the Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2021Article
- Data in a Vacuum? The Desperate Need for a Paradigm Shift to Prevent Heart Failure in Black Americans.Journal of the American Heart Association · 2021Article
- Prevalence of heart disease in patients with mitochondrial abnormalities on skeletal muscle biopsy.Annals of clinical and translational neurology · 2021Article
- Bending Primordial Trajectories Away From Heart Failure.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
- Contemporary Reevaluation of Race and Ethnicity With Outcomes in Heart Failure.Journal of the American Heart Association · 2021Article
- Racial and Ethnic Differences in Biomarkers, Health Status, and Cardiac Remodeling in Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan.Circulation. Heart failure · 2020Article
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Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
Abstract
objectivesThe aim of this study was to evaluate racial differences in arterial elastance (Ea), which reflects the arterial afterload faced by the left ventricle, and its associations with cardiac structure and function. The hypothesis under study was that the left ventricle in blacks displays heightened afterload sensitivity compared with whites.
backgroundChronic increasing in arterial afterload may be an important trigger for left ventricular (LV) remodeling and dysfunction that lead to heart failure. Racial differences in the predisposition to heart failure are well described, but the underlying mechanisms remain unclear.
methodsIn total, 5,727 community-based, older ARIC (Atherosclerosis Risk In Community) study participants (22% black) who underwent echocardiography between 2011 and 2013 were studied.
resultsBlacks were younger (mean age 75 ± 5 years vs. 76 ± 5 years), were more frequently female (66% vs. 57%), and had higher prevalence rates of obesity (46% vs. 31%), hypertension (94% vs. 80%), and diabetes mellitus (47% vs. 34%) than whites. Adjusting for these baseline differences, Ea was higher among blacks (1.96 ± 0.01 mm Hg/ml vs. 1.80 ± 0.01 mm Hg/ml). In blacks, Ea was associated with greater LV remodeling (LV mass index, β = 3.21 ± 0.55 g/m
conclusionsThese community-based data suggest that black Americans display heightened afterload sensitivity as a stimulus for LV structural and functional remodeling, which may contribute to their greater risk for heart failure compared with white Americans.
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