Evidence map›Paper›PMID 28013528›Full record

ArticleClinical & experimental ophthalmology2017

Pathogens and antibiotic sensitivities in endophthalmitis.

Geraldine R Slean, Neal H Shorstein, Liyan Liu, John F Paschal, Kevin L Winthrop, Lisa J Herrinton

Open access · bronzeAbstract read
In one paragraph

Article in Clinical & experimental ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  11. Frontiers in immunology · 2020
    Article
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  13. Prophylactic intracameral cefazolin and postoperative topical moxifloxacin after cataract surgery: endophthalmitis risk reduction and safety results in a 16-year study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Observational
  14. Impact of antibiotic resistance of pathogens and early vitrectomy on the prognosis of infectious endophthalmitis: a 10-year retrospective study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Geraldine R SleanDepartment of Ophthalmology, California Pacific Medical Center, San Francisco, California, USA.
Neal H ShorsteinDepartments of Ophthalmology and Quality, Kaiser Permanente, Walnut Creek, California, USA.
Liyan LiuDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
John F PaschalDepartment of Ophthalmology, Kaiser Permanente, Pasadena, California, USA.
Kevin L WinthropDivision of Infectious Diseases, Department of Ophthalmology, Oregon Health and Sciences University, Portland, Oregon, USA.
Lisa J HerrintonDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Kaiser Permanente · USCalifornia Pacific Medical Center · USKaiser Permanente Walnut Creek Medical Center · USOregon Health & Science University · US

Funding

Comparative Effectiveness of Prophylaxis in Cataract SurgeryR21EY022989 · NEI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HERRINTON, LISA J · 2013 to 2014
$432k
NEI NIH HHS R21 EY022989
6 · The paper itself

Abstract

backgroundAntibiotic prophylaxis in cataract surgery is intended to minimize endophthalmitis. We describe pathogenic organisms, antibiotic sensitivities and antibiotic prophylaxis in culture-proven endophthalmitis cases.

designRetrospective consecutive case series and community-based setting were used.

participantsTwo hundred fifteen cases of endophthalmitis after cataract surgery performed during 2007-2012 in Kaiser Permanente, California. METHODS AND

main outcome measuresDescriptive analysis of isolated organisms and antibiotic sensitivities in relation to antibiotic prophylaxis in culture-proven endophthalmitis cases.

resultsThe majority of culture-confirmed organisms (n = 83) were Gram positive (96%), most notably coagulase-negative Staphylococci (n = 34, 52%), of which all that underwent testing were sensitive to vancomycin (n = 32). Among 19 cases that had received only topical antibiotic prophylaxis, seven (37%) were resistant to the antibiotic given: 50% of cases (5 of 10 isolates) that had received ofloxacin were resistant to this antibiotic, 40% (2 of 5 isolates) that had received gatifloxacin were resistant. In contrast, 100% of cases (n = 4) that had received aminoglycosides were susceptible. Few culture-confirmed cases occurred in patients who received intracameral antibiotic (n = 4).

conclusionsIn cases where fluoroquinolones were administered as antibiotic prophylaxis, isolates demonstrated a degree of bacterial resistance. The majority of endophthalmitis cases isolated occured following topical antibiotic prophylaxis only and were attributed to Gram-positive organisms, while few occurred in association with intracameral antibiotic.

Indexed as

AgedAged, 80 and overAnti-Bacterial AgentsAntibiotic ProphylaxisBacteriaCataract ExtractionEndophthalmitisEye Infections, BacterialFemaleHumansMaleMicrobial Sensitivity TestsPrognosisRetrospective StudiesSurgical Wound InfectionAnti-Bacterial Agentsantibioticcataract surgeryendophthalmitissensitivity

Identifiers

PMID28013528
PMCPMC5483388
OpenAlexW2564516643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.