Evidence map›Paper›PMID 28013412›Full record

ArticlePflugers Archiv : European journal of physiology2017

The inhibition of voltage-gated H

Agustín Asuaje, Paola Smaldini, Pedro Martín, Nicolás Enrique, Alejandro Orlowski, Ernesto A Aiello, Carlos Gonzalez León, Guillermo Docena, Verónica Milesi

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Modulators of the Human Voltage-Gated Proton Channel HPharmaceuticals (Basel, Switzerland) · 2025
    Review
  3. Hv1 channel in immune cells and pharmacology.Pharmacological research · 2025
    Review
  4. Article
  5. Identification of a Novel Structural Class of HJournal of chemical information and modeling · 2024
    Article
  6. Inhibition of the HFrontiers in immunology · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. The Voltage-Gated Hv1 HInternational journal of molecular sciences · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Expression of HProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Agustín AsuajeInstituto de Estudios Inmunológicos y Fisiopatológicos (IIFP, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Paola SmaldiniInstituto de Estudios Inmunológicos y Fisiopatológicos (IIFP, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Pedro MartínInstituto de Estudios Inmunológicos y Fisiopatológicos (IIFP, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina. pedromartinv@gmail.com.
Nicolás EnriqueInstituto de Estudios Inmunológicos y Fisiopatológicos (IIFP, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Alejandro OrlowskiCentro de Investigaciones Cardiovasculares (CIC, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, Argentina.
Ernesto A AielloCentro de Investigaciones Cardiovasculares (CIC, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, Argentina.
Carlos Gonzalez LeónCentro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Chile, Pasaje Harrington 287, Playa Ancha, Valparaíso, Chile.
Guillermo DocenaInstituto de Estudios Inmunológicos y Fisiopatológicos (IIFP, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Verónica MilesiInstituto de Estudios Inmunológicos y Fisiopatológicos (IIFP, CONICET-Universidad Nacional de la Plata), Fac. de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.
Universidad Nacional de La Plata · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARCentro de Investigaciones Cardiovasculares · ARUniversity of Valparaíso · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular energetic deregulation is widely known to produce an overproduction of acidic species in cancer cells. This acid overload must be counterbalanced with a high rate of H

Indexed as

Antineoplastic AgentsApoptosisCell DeathCell LineCell SurvivalHumansHydrogen-Ion ConcentrationIon Channel GatingIon ChannelsJurkat CellsNADPH OxidasesProtonsReactive Oxygen SpeciesT-LymphocytesZincAntineoplastic AgentsHVCN1 protein, humanIon ChannelsNADPH OxidasesProtonsReactive Oxygen SpeciesZincApoptosisCancerHVCN1Intracellular pHLeukemiaVoltage-gated proton channel

Identifiers

PMID28013412
OpenAlexW2565003033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.