ArticleEvolution, medicine, and public health2016
Lethal gene drive selects inbreeding.
Article in Evolution, medicine, and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed.
- Seed dormancy shapes gene drive dynamics in plants.Nature plants · 2026Article
- Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions?Genetics · 2025Article
- Gene drives: an alternative approach to malaria control?Gene therapy · 2025Review
- Modeling the evolution of Schizosaccharomyces pombe populations with multiple killer meiotic drivers.G3 (Bethesda, Md.) · 2024Article
- Parental-effect gene-drive elements under partial selfing, or why dobioRxiv : the preprint server for biology · 2024Article
- Selfing Promotes Spread and Introgression of Segregation Distorters in Hermaphroditic Plants.Molecular biology and evolution · 2024Article
- Cleave and Rescue gamete killers create conditions for gene drive in plants.Nature plants · 2024Article
- Cleave and Rescue gamete killers create conditions for gene drive in plants.bioRxiv : the preprint server for biology · 2024Article
- Predicting thresholds for population replacement gene drives.BMC biology · 2024Article
- Manipulating the Destiny of Wild Populations Using CRISPR.Annual review of genetics · 2023Review
- Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control.PLoS neglected tropical diseases · 2022Article
- Gene drive escape from resistance depends on mechanism and ecology.Evolutionary applications · 2022Article
- Diverse mating phenotypes impact the spread ofeLife · 2021Article
- Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Modeling CRISPR gene drives for suppression of invasive rodents using a supervised machine learning framework.PLoS computational biology · 2021Article
- Gene drive strategies of pest control in agricultural systems: Challenges and opportunities.Evolutionary applications · 2021Article
- Evading resistance to gene drives.Genetics · 2021Article
- Suppressing evolution in genetically engineered systems through repeated supplementation.Evolutionary applications · 2021Article
- Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles.Molecular ecology · 2021Article
- Selfing is the safest sex foreLife · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
The use of 'selfish' gene drive systems to suppress or even extinguish populations has been proposed on theoretical grounds for almost half a century. Creating these genes has recently become possible with CRISPR technology. One seemingly feasible approach, originally proposed by Burt, is to create a homing endonuclease gene (HEG) that inserts into an essential gene, enabling heterozygote viability but causing homozygote lethality. With 100% segregation distortion in gametes, such genes can cause profound population suppression if resistance does not evolve. Here, population genetic models are used to consider the evolution of inbreeding (specifically selfing) as a possible response to a recessively lethal HEG with complete segregation distortion. Numerical analyses indicate a rich set of outcomes, but selfing often evolves in response to the HEG, with a corresponding partial restoration of mean fitness. Whether selfing does indeed evolve and its effect in restoring fitness depends heavily on the magnitude of inbreeding depression. Overall, these results point toward an underappreciated evolutionary response to block the harmful effects of a selfish gene. They raise the possibility that extreme population suppression may be resisted by mechanisms that are independent of the molecular basis of gene drive. At the same time, the evolution of inbreeding is not assured even if the genetic basis for inbreeding is present. As the models here strictly apply to hermaphrodites (plants), an important next step is to consider inbreeding in populations with separate sexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.