ArticleToxicological sciences : an official journal of the Society of Toxicology2017
Effects of an Environmentally Relevant Phthalate Mixture on Cultured Mouse Antral Follicles.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 99 citations in OpenAlex.
- Review
- Effects of Phthalate Metabolite Mixture Exposure on Mouse Oocyte Development.bioRxiv : the preprint server for biology · 2026Article
- Computational identification of diagnostic biomarkers linking Dibutyl phthalate exposure to ovarian cancer through network toxicology and machine learning.Discover oncology · 2026Article
- An environmentally relevant phthalate mixture impairs ovulatory prostaglandin and progesterone receptor pathways in human granulosa cells in vitro.Environment international · 2026Article
- Exploratory assessment of preconception phthalate exposure on pregnancy and offspring health outcomes in mice.Journal of the Endocrine Society · 2026Article
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.Environmental pollution (Barking, Essex : 1987) · 2025Article
- The inhibition of prostaglandin production during ovulation by exposure to a phthalate mixture is circumvented by cAMP analogue supplementation in a human granulosa cell model.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Effects of phthalate exposure on human ovarian extracellular matrix composition: insights from a 3D spheroid model.Environmental research · 2025Article
- Epidemiologically relevant phthalate mixture and mono(2-ethyl-5-hydroxyhexyl) phthalate exposure alter cell energy metabolism in primary mouse granulosa cells.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Neonatal exposure to an environmentally relevant phthalate mixture alters ovarian function in mice.Toxicology and applied pharmacology · 2025Article
- Bayesian benchmark dose modeling analysis and derivation of points of departure for female reproductive toxicity following exposure to di(2-ethylhexyl) phthalate (DEHP) - effects on reproductive hormones, folliculogenesis and estrous cyclicity.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.bioRxiv : the preprint server for biology · 2025Article
- Forever particles: histochemistry in the plasticene age.European journal of histochemistry : EJH · 2025Review
- N-actylcysteine inhibits diethyl phthalate-induced inflammation via JNK and STAT pathway in RAW264.7 macrophages.BMC molecular and cell biology · 2025Article
- Single-cell RNA-seq reveals that granulosa cells are a target of phthalate toxicity in the ovary.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Prenatal exposure to an environmentally relevant phthalate mixture alters oxidative stress, apoptosis, cell cycle regulators, and steroidogenic factors in the ovaries of F1 mice.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- A common phthalate replacement disrupts ovarian function in young adult mice.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- In Vitro Toxicity of a DEHP and Cadmium Mixture on Sheep Cumulus-Oocyte Complexes.International journal of molecular sciences · 2024Article
- Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Quantitative label-free proteomic analysis of mouse ovarian antral follicles following oral exposure to a human-relevant mixture of three phthalates.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Phthalates are used in building materials, medical devices, and personal care products. Most studies on phthalates have focused on single phthalates, but it is important to study mixtures of phthalates because humans are exposed to such mixtures daily. We tested the hypothesis that phthalate mixture exposure decreases antral follicle growth, compromises steroidogenic capacity, and induces atresia. Antral follicles from adult CD-1 mice were cultured with vehicle control or phthalate mixture (1-500 µg/ml) for 96 h. The mixture was made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% diisononyl phthalate, 8% diisobutyl phthalate, and 5% benzylbutyl phthalate. During culture, antral follicle diameters were measured every 24 h to monitor growth. After culture, media were subjected to measurements of sex steroid hormones and follicles were subjected to evaluation of gene expression and atresia. The phthalate mixture (100 and 500 µg/ml) decreased antral follicle growth starting at 24 h compared to controls. The mixture at 10, 100, and 500 µg/ml also decreased androstenedione, testosterone, estrone, and estradiol levels compared to control. The mixture (10, 100, and 500 µg/ml) reduced atresia rating, but it induced more oocyte fragmentation compared to control. The phthalate mixture at different doses adversely affected cell cycle regulators, antioxidant enzymes, apoptotic factors, steroidogenic enzymes, and receptors. Collectively, these data indicate that exposure to an environmentally relevant phthalate mixture reduces antral follicle growth, induces oocyte fragmentation, and decreases hormone production by adversely affecting the expression of cell cycle regulators, apoptotic factors, steroidogenic enzymes, and receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.