Evidence map›Paper›PMID 28013031›Full record

ReviewJournal of molecular biology2017

Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration.

Nilkantha Sen

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The Role of Hydrogen Sulfide (HInternational journal of molecular sciences · 2023
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. HJournal of nanobiotechnology · 2025
    Article
  6. Article
  7. Review
  8. Hydrogen Sulfide (HPathogens (Basel, Switzerland) · 2025
    Article
  9. Hydrogen Sulfide (HInternational journal of molecular sciences · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Signaling Paradigms of HAntioxidants (Basel, Switzerland) · 2024
    Review
  15. Review
  16. Article
  17. Theranostic Fluorescent Probes.Chemical reviews · 2024
    Review
  18. HCells · 2024
    Article
  19. Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Nilkantha SenDepartment of Neuroscience and Regenerative Medicine, Augusta University, 1120 15th Street, CA 2018, Augusta, GA, 30907, USA. Electronic address: nsen@augusta.edu.

Funding

Molecular Mechanisms underlying vision impairment after TBIR01EY025622 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEN, NILKANTHA · 2016 to 2020
$1.9M
Development of therapeutic strategy against TBI based on hydrogen sulfideR01NS094516 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEN, NILKANTHA · 2016 to 2020
$1.7M
NEI NIH HHS R01 EY025622NINDS NIH HHS R01 NS094516
6 · The paper itself

Abstract

Hydrogen sulfide (H2S), a novel gasotransmitter, is endogenously synthesized by multiple enzymes that are differentially expressed in the peripheral tissues and central nervous systems. H2S regulates a wide range of physiological processes, namely cardiovascular, neuronal, immune, respiratory, gastrointestinal, liver, and endocrine systems, by influencing cellular signaling pathways and sulfhydration of target proteins. This review focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspects of several biological processes such as autophagy, inflammation, proliferation and differentiation of stem cell, cell survival/death, and cellular metabolism under both physiological and pathological conditions. Moreover, we highlighted the cross-talk between nitric oxide and H2S in several bilogical contexts.

Indexed as

Signal TransductionAnimalsBrain Injuries, TraumaticCell CycleCell DifferentiationCell ProliferationFibrosisGasotransmittersHumansHydrogen SulfideIschemiaMetabolic DiseasesNeurodegenerative DiseasesNeurotransmitter AgentsNitric OxideStem CellsGasotransmittersHydrogen SulfideNeurotransmitter AgentsNitric OxideCBSCSEhydrogen sulfidesulfhydration

Identifiers

PMID28013031
PMCPMC5276714

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.