Evidence map›Paper›PMID 28013000›Full record

ArticleExperimental neurology2017

Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy.

Jesus-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jesus-Servando Medel-MatusDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Don ShinDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Raman SankarDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Children's Discovery and Innovation Institute, UCLA, Los Angeles, CA, USA.
Andrey MazaratiDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA; Children's Discovery and Innovation Institute, UCLA, Los Angeles, CA, USA. Electronic address: mazarati@ucla.edu.
University of California, Los Angeles · US

Funding

Mechanisms of comorbidity between epilepsy and depressionR01NS065783 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZARATI, ANDREY M · 2010 to 2017
$2.9M
Optogenetic treatment of epilepsyassociatedR21NS089396 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, MAZARATI, ANDREY M · 2014 to 2015
$424k
NINDS NIH HHS R01 NS065783NINDS NIH HHS R21 NS089396
6 · The paper itself

Abstract

Status epilepticus (SE) in rats, along with chronic epilepsy, leads to the development of behavioral impairments resembling depressive disorder and/or attention deficit/hyperactivity disorder (ADHD), thus reflecting respective comorbidities in epilepsy patients. Suppressed neurotransmitter tone in the raphe nucleus (RN)-prefrontal cortex (PFC) serotonergic pathway and in the locus coeruleus (LC)-PFC noradrenergic pathway underlies depressive- and impulsive-like behavioral deficits respectively. We examined possible mechanisms leading to the monoamine dysfunction in brainstem efferents, namely modulatory effects of the neuropeptide galanin on serotonin (5-HT) and norepinephrine (NE) signaling. SE was induced in young adult male Wistar rats by LiCl and pilocarpine. Epileptic rats were categorized vis-à-vis behavioral deficits as not impaired, "depressed" and "impulsive". Depressive- and impulsive-like behaviors were examined in the forced swimming test (FST). The strength of serotonergic transmission in RN-PFC and of noradrenergic transmission in LC-PFC was analyzed using in vivo fast scan cyclic voltammetry. Galanin receptor type 1 (GalR1)/type 2 (GalR2) antagonist M40, and a preferential GalR2 antagonist M871 were administered over 3days locally into either RN or LC by means of ALZET osmotic minipumps connected to locally implanted infusion cannulas. Intra-RN injection of M40 improved serotonergic tone and depressive-like behavior in epileptic "depressed" rats. Intra-LC injection of M40 improved noradrenergic tone and impulsive-like behavior in epileptic "impulsive" rats. The effects of M40 were only observed in impaired subjects. The treatment did not modify neurotransmission and behavior in naïve and epileptic not impaired rats; in "depressed" rats the effects were limited to serotonergic transmission and immobility, while in "impulsive" rats - to noradrenergic transmission and struggling behavior. Intra-RN administration of M871 exacerbated depressive-like behavior, but had no effects on any other of the examined parameters in any category of animals. These findings suggest that endogenous galanin, acting through GalR1 may be involved in the pathophysiology of epilepsy-associated depression and ADHD via inhibiting RN-PFC serotonergic and LC-PFC noradrenergic transmissions respectively.

Indexed as

DepressionAnimalsAntidepressive AgentsBiogenic MonoaminesDisease Models, AnimalDrug Delivery SystemsGalactolipidsGalaninImpulsive BehaviorLithium ChlorideLocus CoeruleusMaleMuscarinic AgonistsPeptide FragmentsPilocarpineRaphe NucleiAntidepressive AgentsBiogenic Monoaminesdi-O-12-methyl-tetradecanoyl-3-O-galactopyranosyl-glycerolGalactolipidsGalaninLithium ChlorideM40Muscarinic AgonistsPeptide FragmentsPilocarpineSerotoninAttention deficit/hyperactivity disorderComorbidityDepressionEpilepsyGalaninLocus coeruleusNorepinephrinePrefrontal cortexRaphe nucleusSerotonin

Identifiers

PMID28013000
PMCPMC5285493
OpenAlexW2567394626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.