ArticleExperimental gerontology2018
Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise.
Article in Experimental gerontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Immunosenescence accelerates atherosclerosis development in AAV-PCSK9 mouse model.GeroScience · 2025Article
- Early life thymectomy induces arterial dysfunction in mice.GeroScience · 2024Article
- Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age.Aging cell · 2023Article
- Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders.Molecular biology reports · 2022Review
- Flavanol Consumption in Healthy Men Preserves Integrity of Immunological-Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis.Molecular nutrition & food research · 2022Article
- Extracellular Matrix in Aging Aorta.Frontiers in cell and developmental biology · 2022Review
- Vascular Ageing and Aerobic Exercise.International journal of environmental research and public health · 2021Review
- T cells mediate cell non-autonomous arterial ageing in mice.The Journal of physiology · 2021Article
- Article
- The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.PloS one · 2021Article
- Voluntary Exercise Suppresses Choroidal Neovascularization in Mice.Investigative ophthalmology & visual science · 2020Article
- Inflammation as a mediator of arterial ageing.Experimental physiology · 2019Review
- MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells.Journal of biomedical science · 2019Article
- Voluntary Wheel Running: A Useful Rodent Model for Investigating the Mechanisms of Stress Robustness and Neural Circuits of Exercise Motivation.Current opinion in behavioral sciences · 2019Article
- The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age.Scientific reports · 2019Article
- Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease.Circulation research · 2018Review
- Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment.Journal of neuroinflammation · 2018Article
- Transcriptome Analysis of the Thymus in Short-Term Calorie-Restricted Mice Using RNA-seq.International journal of genomics · 2018Article
- T Cells in Adipose Tissue in Aging.Frontiers in immunology · 2018Review
- Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries.Cytokine · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Age-related arterial inflammation is associated with dysfunction of the arteries and increased risk for cardiovascular disease. To determine if aging increases arterial immune cell infiltration as well as the populations of immune cells principally involved, we tested the hypothesis that large elastic and resistance arteries in old mice would exhibit increased immune cell infiltration compared to young controls. Additionally, we hypothesized that vasoprotective lifestyle interventions such as lifelong caloric restriction or 8weeks of voluntary wheel running would attenuate age-related arterial immune cell infiltration. The aorta and mesenteric vasculature with surrounding perivascular adipose was excised from young normal chow (YNC, 4-6months, n=10), old normal chow (ONC, 28-29months, n=11), old caloric restricted (OCR, 28-29months, n=9), and old voluntary running (OVR, 28-29months, n=5) mice and digested to a single cell suspension. The cells were then labeled with antibodies against CD45 (total leukocytes), CD3 (pan T cells), CD4 (T helper cells), CD8 (cytotoxic T cells), CD19 (B cells), CD11b, and F4/80 (macrophages) and analyzed by flow cytometry. Total leukocytes, T cells (both CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.