ReviewThe Journal of allergy and clinical immunology2017
Idiopathic systemic capillary leak syndrome (Clarkson disease).
Review in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.
- Idiopathic systemic capillary leak syndrome (Clarkson syndrome) in childhood: systematic literature review.European journal of pediatrics · 2018Pooled it
- Precision Monitoring in a Sepsis Mimic: A Case Report of Idiopathic Capillary Leak Syndrome in the Surgical ICU.Healthcare (Basel, Switzerland) · 2026Article
- When the electrocardiogram goes quiet: transient low voltage in systemic capillary leak syndrome-associated myocardial oedema-a case report.European heart journal. Case reports · 2026Article
- Idiopathic systemic capillary leak syndrome and related shock in PICU: an underdiagnosed disease?Journal of anesthesia, analgesia and critical care · 2026Article
- Neonatal Noonan syndrome with acute kidney injury and systemic capillary leak syndrome caused by aFrontiers in pediatrics · 2026Article
- Identification of ERN1 as a Potential Context-Dependent Biomarker in Chronic Obstructive Pulmonary Disease Based on Bioinformatics Analysis of GSE57148 Dataset.International journal of chronic obstructive pulmonary disease · 2026Article
- Ultrastructure of the small vessels in the myocardium in a patient with fatal systemic capillary leak syndrome.Medical molecular morphology · 2025Article
- Capillary leak syndrome in sepsis: the role of intrinsic coagulation pathway activation.BMC infectious diseases · 2025Article
- [Systemic capillary leak syndrome: A case of severe presentation and treatment response].Anales del sistema sanitario de Navarra · 2025Article
- Immunotherapy-associated capillary leak syndrome in endometrial cancer: a case report and review of the literature.Gynecologic oncology reports · 2025Article
- A 74-Year-Old Man with Refractory Hypotension in the Setting of COVID-19 Infection.Annals of the American Thoracic Society · 2025Article
- Systemic capillary leak syndrome: a nosological entity that the nephrologist must be aware of.Journal of nephrology · 2025Review
- Clarkson disease in critically and non-critically ill patients: insights from the Italian IRIS-CLS registry.Internal and emergency medicine · 2025Article
- Characteristics of SARS-CoV-2-associated severe episodes of monoclonal gammopathy-associated capillary leak syndrome (Clarkson disease).Annals of intensive care · 2025Article
- Clinical application of acute Q fever -induced systemic capillary leak syndrome in a patient by using metagenomic next-generation sequencing: a case report and literature review.BMC infectious diseases · 2025Review
- The systemic capillary leak syndrome following COVID-19 vaccine.Human vaccines & immunotherapeutics · 2024Article
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- Systemic capillary leak syndrome.Nature reviews. Disease primers · 2024Review
- A case of frequent of prerenal acute kidney injury attacks: importance of recognizing systemic capillary leak syndrome: a case report.The Journal of international medical research · 2024Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byReply.2018
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In 1960, Dr Bayard Clarkson described a woman experiencing sporadic recurrent episodes of shock and anasarca. Plasma from an acute attack induced a shock-like syndrome when injected into rats. The enigmatic systemic capillary leak syndrome (SCLS) named for Dr Clarkson is characterized by transient and severe but reversible hemoconcentration and hypoalbuminemia caused by leakage of fluids and macromolecules into tissues. Although less than 500 cases of SCLS have been reported in the literature since 1960, the condition is probably underdiagnosed because of a lack of awareness and a high mortality without treatment. Allergists should be vigilant of this diagnosis because its presentation can resemble more common plasma leakage syndromes, including angioedema or systemic anaphylaxis. Although the precise molecular cause of SCLS remains unknown, substantial advances over the last 5 years have increased our understanding of SCLS pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.