ArticleMicrobes and infection2017
Pathogenic conversion of coagulase-negative staphylococci.
Article in Microbes and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Global prevalence of macrolide-resistantFrontiers in microbiology · 2025Pooled it
- Prevalence and antimicrobial resistance of coagulase negative staphylococci clinical isolates from Ethiopia: a meta-analysis.BMC microbiology · 2018Pooled it
- Patterns, Associated Factors, and Anatomical Concordance of Nasal and ThroatMicroorganisms · 2026Article
- Article
- CodY controls the SaeR/S two-component system by modulating branched-chain fatty acid synthesis inJournal of bacteriology · 2024Article
- Risk factors and prediction model construction for peripherally inserted central catheter-related infections.Heliyon · 2024Article
- Analysis of the Presence of the Virulence and Regulation Genes fromInternational journal of environmental research and public health · 2023Article
- The Fusaric Acid Derivative qy17 InhibitsFrontiers in microbiology · 2022Article
- Epidemiology and Pathogenesis ofPolish journal of microbiology · 2021Review
- Coagulase-negative staphylococci (CoNS) as a significant etiological factor of laryngological infections: a review.Annals of clinical microbiology and antimicrobials · 2020Review
- Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms.Current opinion in microbiology · 2020Review
- Antimicrobial resistance patterns and biofilm formation of coagulase-negative Staphylococcus species isolated from subclinical mastitis cow milk samples submitted to the Onderstepoort Milk Laboratory.BMC veterinary research · 2019Article
- Influence of media on the differentiation of Staphylococcus spp. by volatile compounds.Journal of breath research · 2019Article
- Time-Dependent Changes in the Intestinal Microbiome of Gilts Exposed to Low Zearalenone Doses.Toxins · 2019Article
- Nutritional Regulation of the Sae Two-Component System by CodY in Staphylococcus aureus.Journal of bacteriology · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Humans and animals are colonized by members of the genus Staphylococcus, however only some of these species evolved to cause invasive disease. The genetic basis for conversion of commensal staphylococci into pathogens is not known. We hypothesized that Staphylococcus aureus genes for coagulation and agglutination in vertebrate blood (coa, vwb and clfA) may support pathogenic conversion. Expression of coa and vwb in Staphylococcus epidermidis or Staphylococcus simulans supported a coagulase-positive phenotype but not the ability to cause disease in a mouse model of bloodstream infection. However, the simultaneous expression of coa, vwb and clfA in coagulase-negative staphylococci enabled bacterial agglutination in plasma and enhanced survival of S. simulans in human whole blood. Agglutination of S. simulans in the bloodstream of infected mice upon expression of coa, vwb and clfA provided also a mean for dissemination and replication in distal organs. Thus, the acquisition of genes for bacterial agglutination with fibrin appear sufficient for the conversion of commensal staphylococci into invasive pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.