ArticlePsychoneuroendocrinology2017
Behavioral and physiological consequences of enrichment loss in rats.
Article in Psychoneuroendocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Early-life environmental enrichment reduces anxiety and induces sex-dependent neuroplasticity in hypothalamic oxytocin and vasopressin neurons.Journal of neuroendocrinology · 2026Article
- Effects of enrichment removal on cognitive judgement bias of mice: a comparison of two paradigms.Frontiers in veterinary science · 2026Article
- The impact of housing and high-fructose diet on behavior and cardiovascular response to eucalyptus wildfire smoke in WKY rats.Journal of toxicology and environmental health. Part A · 2026Article
- Prefrontal cortical microglial transcriptome relates to mouse offspring executive function deficits after perinatal opioid exposure in a sex-dependent manner.Brain, behavior, and immunity · 2025Article
- Epigenetics and suicidal behavior in adolescents: a critical review.Epigenomics · 2025Review
- Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes.Animal microbiome · 2025Article
- Early resistance rehabilitation improves functional regeneration following segmental bone defect injury.NPJ Regenerative medicine · 2024Article
- Social and nonsocial environmental loss have differential effects on ventral hippocampus-dependent behavior and inhibitory synaptic markers in adult male mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Husbandry Conditions and Welfare State of Pet Chinchillas (Animals : an open access journal from MDPI · 2024Article
- Effects of temporary access to environmental enrichment on measures of laboratory mouse welfare.Scientific reports · 2024Article
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.Neurobiology of stress · 2024Article
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.bioRxiv : the preprint server for biology · 2024Article
- Resource choice during ontogeny enhances both the short- and longer-term welfare of laying hen pullets.Scientific reports · 2024Article
- Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice.Neurotoxicology · 2023Article
- Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix.Molecular psychiatry · 2023Article
- The emotional impact of disrupted environmental contexts: Enrichment loss and coping profiles influence stress response recovery in Long-Evans rats.Journal of neuroendocrinology · 2022Article
- Providing Environmental Enrichment without Altering Behavior in Male and Female Wistar Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Use of prepubertal environment enrichment to prevent dopamine dysregulation in a neurodevelopmental rat model of schizophrenia risk.STAR protocols · 2022Article
- Long-lasting housing environment manipulation and acute loss of environmental enrichment impact BALB/c mice behaviour in multiple functional domains.The European journal of neuroscience · 2022Article
- Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Significant loss produces the highest degree of stress and compromised well-being in humans. Current rodent models of stress involve the application of physically or psychologically aversive stimuli, but do not address the concept of loss. We developed a rodent model for significant loss, involving removal of long-term access to a rewarding enriched environment. Our results indicate that removal from environmental enrichment produces a profound behavioral and physiological phenotype with depression-like qualities, including helplessness behavior, hypothalamo-pituitary-adrenocortical axis dysregulation and overeating. Importantly, this enrichment removal phenotype was prevented by antidepressant treatment. Furthermore, the effects of enrichment removal do not occur following relief from chronic stress and are not duplicated by loss of exercise or social contact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.