Evidence map›Paper›PMID 28012260›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2017

Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo-Osmium Complex in Human Ovarian Cancer Cells.

Carlos Sanchez-Cano, Isolda Romero-Canelón, Yang Yang, Ian J Hands-Portman, Sylvain Bohic, Peter Cloetens, Peter J Sadler

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Recent Advances in Anticancer Research of Osmium and Rhodium Complexes.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Single-Cell Chemistry of Photoactivatable Platinum Anticancer Complexes.Journal of the American Chemical Society · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Carlos Sanchez-CanoDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID http://orcid.org/0000-0002-9522-0019
Isolda Romero-CanelónDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID http://orcid.org/0000-0003-3847-4626
Yang YangID16A beamline, ESRF, The European Synchrotron, 71 Avenue des Martyrs, 3800, Grenoble, France.ORCID http://orcid.org/0000-0001-5318-5385
Ian J Hands-PortmanSchool of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.ORCID http://orcid.org/0000-0002-8895-2342
Sylvain BohicID16A beamline, ESRF, The European Synchrotron, 71 Avenue des Martyrs, 3800, Grenoble, France.ORCID http://orcid.org/0000-0001-6355-7592
Peter CloetensID16A beamline, ESRF, The European Synchrotron, 71 Avenue des Martyrs, 3800, Grenoble, France.ORCID http://orcid.org/0000-0002-4129-9091
Peter J SadlerDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID http://orcid.org/0000-0001-9160-1941
University of Warwick · GBEuropean Synchrotron Radiation Facility · FRInserm · FR

Funding

Medical Research Council G0701062Wellcome Trust
6 · The paper itself

Abstract

A variety of transition metal complexes exhibit anticancer activity, but their target sites in cells need to be identified and mechanisms of action elucidated. Here, it was found that the sub-cellular distribution of [Os(η

Indexed as

Antineoplastic AgentsCell Cycle CheckpointsCell Line, TumorCoordination ComplexesCymenesFemaleFluorescent DyesHumansMicroscopy, FluorescenceMitochondriaMonoterpenesNanostructuresOsmiumOvarian NeoplasmsReactive Oxygen SpeciesSynchrotrons4-cymeneAntineoplastic AgentsCoordination ComplexesCymenesFluorescent DyesMonoterpenesOsmiumReactive Oxygen Speciesbioinorganic chemistryelemental mappingmetallodrugsorganometallic complexesX-ray fluorescence

Identifiers

PMID28012260
PMCPMC5412901
OpenAlexW2565191236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.