Evidence map›Paper›PMID 28012156›Full record

ArticleJournal of physiology and biochemistry2017

Sexual dimorphism in obesity-related genes in the epicardial fat during aging.

Caitlin Kocher, Matthew Christiansen, Sarah Martin, Christopher Adams, Paulette Wehner, Todd Gress, Nalini Santanam

Open access · greenAbstract readValidation Study
In one paragraph

Article in Journal of physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Sex Differences in Adiposity and Cardiovascular Diseases.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Sex Differences in Adipose Tissue CD8Frontiers in immunology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Caitlin KocherDepartment of Pharmacology, Physiology, & Toxicology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV, 25755, USA.
Matthew ChristiansenDepartment of Pharmacology, Physiology, & Toxicology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV, 25755, USA.
Sarah MartinDepartment of Pharmacology, Physiology, & Toxicology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV, 25755, USA.
Christopher AdamsDepartment of Medicine and Cardiology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV, 25755, USA.
Paulette WehnerDepartment of Medicine and Cardiology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV, 25755, USA.
Todd GressDepartment of Medicine and Cardiology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV, 25755, USA.
Nalini SantanamDepartment of Pharmacology, Physiology, & Toxicology, Joan C Edwards School of Medicine, Marshall University, One John Marshall Dr, Huntington, WV, 25755, USA. santanam@marshall.edu.ORCID http://orcid.org/0000-0003-3343-6081
Marshall University · US

Funding

WVU &MU NEW FACULTY GRANTSP20RR016477 · NCRR · MARSHALL UNIVERSITY · PI RANKIN, GARY O · 2001 to 2011
$35.5M
Oxidized Lipids in Cardiovascular DiseaseR01HL074239 · NHLBI · MARSHALL UNIVERSITY · PI SANTANAM, NALINI · 2004 to 2008
$1.8M
ADAR2 and Adipose Dysfunction in AgingR15AG051062 · NIA · MARSHALL UNIVERSITY · PI SANTANAM, NALINI · 2015 to 2015
$357k
NCRR NIH HHS P20 RR016477NHLBI NIH HHS R01 HL074239NIA NIH HHS R15 AG051062
6 · The paper itself

Abstract

Aging increases the risk of cardiovascular disease and metabolic syndrome. Alterations in epicardial fat play an important pathophysiological role in coronary artery disease and hypertension. We investigated the impact of normal aging on obesity-related genes in epicardial fat. Sex-specific changes in obesity-related genes with aging in epicardial fat (EF) were determined in young (6 months) and old (30/36 months) female and male, Fischer 344 × Brown Norway hybrid (FBN) rats, using a rat obesity RT

Indexed as

AdiposityAgingGene Expression Regulation, DevelopmentalAdipose Tissue, WhiteAnimalsCoronary Artery DiseaseCrosses, GeneticFemaleGene Expression ProfilingHypertensionMaleMyocardiumObesityOrgan SizePericardiumRatsAdipose dysfunctionEctopic fatExpression profileGender differences

Identifiers

PMID28012156
PMCPMC5572646
OpenAlexW2566052109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.