Evidence map›Paper›PMID 28012137›Full record

ArticleJournal of structural and functional genomics2016

VaProS: a database-integration approach for protein/genome information retrieval.

Takashi Gojobori, Kazuho Ikeo, Yukie Katayama, Takeshi Kawabata, Akira R Kinjo, Kengo Kinoshita, Yeondae Kwon, Ohsuke Migita, Hisashi Mizutani, Masafumi Muraoka and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of structural and functional genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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  5. Biophysics at Waseda University.Biophysical reviews · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Takashi GojoboriComputational Bioscience Research Center, Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.
Kazuho IkeoNational Institute of Genetics, Shizuoka, 411-8540, Mishima, Japan.
Yukie KatayamaGraduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Takeshi KawabataInstitute for Protein Research, Osaka University, Suita, Osaka, 565-0871, Japan.
Akira R KinjoInstitute for Protein Research, Osaka University, Suita, Osaka, 565-0871, Japan.
Kengo KinoshitaGraduate School of Information Sciences, Tohoku University, Miyagi, Sendai, 980-8597, Japan.
Yeondae KwonGraduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Ohsuke MigitaDepartment of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan.
Hisashi MizutaniNational Institute of Genetics, Shizuoka, 411-8540, Mishima, Japan.
Masafumi MuraokaNational Institute of Genetics, Shizuoka, 411-8540, Mishima, Japan.
Koji NagataGraduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Satoshi OmoriGraduate School of Information Sciences, Tohoku University, Miyagi, Sendai, 980-8597, Japan.
Hideaki SugawaraNational Institute of Genetics, Shizuoka, 411-8540, Mishima, Japan.
Daichi YamadaCenter for Informational Biology, Ochanomizu University, 2-1-1, Otsuka, Bunkyo, Tokyo, 112-8610, Japan.
Kei YuraNational Institute of Genetics, Shizuoka, 411-8540, Mishima, Japan. yura.kei@ocha.ac.jp.ORCID http://orcid.org/0000-0003-0197-5478
National Institute of Genetics · JPThe University of Tokyo · JPProtein Research Foundation · JPTohoku University · JPOtsuka (Japan) · JPSt. Marianna University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Life science research now heavily relies on all sorts of databases for genome sequences, transcription, protein three-dimensional (3D) structures, protein-protein interactions, phenotypes and so forth. The knowledge accumulated by all the omics research is so vast that a computer-aided search of data is now a prerequisite for starting a new study. In addition, a combinatory search throughout these databases has a chance to extract new ideas and new hypotheses that can be examined by wet-lab experiments. By virtually integrating the related databases on the Internet, we have built a new web application that facilitates life science researchers for retrieving experts' knowledge stored in the databases and for building a new hypothesis of the research target. This web application, named VaProS, puts stress on the interconnection between the functional information of genome sequences and protein 3D structures, such as structural effect of the gene mutation. In this manuscript, we present the notion of VaProS, the databases and tools that can be accessed without any knowledge of database locations and data formats, and the power of search exemplified in quest of the molecular mechanisms of lysosomal storage disease. VaProS can be freely accessed at http://p4d-info.nig.ac.jp/vapros/ .

Indexed as

Computational BiologyDatabases, GeneticGenomeInternetSoftwareAnimalsHumansMiceProtein ConformationRatsSequence Analysis, DNABig data analysisDatabase integrationLysosomal storage diseaseProtein 3D structure

Identifiers

PMID28012137
PMCPMC5274651
OpenAlexW2561357440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.