Evidence map›Paper›PMID 28012135›Full record

ArticleLipids2017

Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease.

Yanjun Liu, Di Shi, Yingying Tian, Yuntao Liu, Qiping Zhan, Jie Xu, Jingfeng Wang, Changhu Xue

Abstract read
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In one paragraph

Article in Lipids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  4. Holy Basil (Plants (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yanjun LiuCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong Province, China.
Di ShiCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong Province, China.
Yingying TianCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong Province, China.
Yuntao LiuShandong Oriental Ocean Sci-tech Co., Ltd., Yantai, 264003, Shandong Province, China.
Qiping ZhanCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong Province, China.
Jie XuCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong Province, China.
Jingfeng WangCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong Province, China.
Changhu XueCollege of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong Province, China. xuechanghuouc@163.com.
Ocean University of China · CNShandong Institute of Business and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Disturbed cholesterol metabolism plays a crucial role in the development of NAFLD. The present study was conducted to evaluate the effects of EPA-PC extracted from sea cucumber on liver steatosis and cholesterol metabolism in NAFLD. Male Wistar rats were randomly divided into seven groups (normal control group, model group, lovastatin group, low- and high-dose EPA groups, and low- and high-dose EPA-PC groups). Model rats were established by administering a diet containing 1% orotic acid. To determine the possible cholesterol metabolism promoting mechanism of EPA-PC, we analyzed the transcription of key genes and transcriptional factors involved in hepatic cholesterol metabolism. EPA-PC dramatically alleviated hepatic lipid accumulation, reduced the serum TC concentration, and elevated HDLC levels in NAFLD rats. Fecal neutral cholesterol excretion was also promoted by EPA-PC administration. Additionally, EPA-PC decreased the mRNA expression of hydroxymethyl glutaric acid acyl (HMGR) and cholesterol 7α-hydroxylase (CYP7A), and increased the transcription of sterol carrying protein 2 (SCP2). Moreover, EPA-PC stimulated the transcription of peroxisome proliferators-activated receptor α (PPARα) and adenosine monophosphate activated protein kinase (AMPK) as well as its modulators, liver kinase B1 (LKB1) and Ca

Indexed as

AnimalsCarrier ProteinsCholesterolCholesterol 7-alpha-HydroxylaseDisease Models, AnimalEicosapentaenoic AcidGene Expression ProfilingGene Expression RegulationHydroxymethylglutaryl CoA ReductasesMaleNon-alcoholic Fatty Liver DiseaseOrotic AcidPhosphatidylcholinesRandom AllocationRatsRats, WistarCarrier ProteinsCholesterolCholesterol 7-alpha-HydroxylaseEicosapentaenoic AcidHydroxymethylglutaryl CoA ReductasesOrotic AcidPhosphatidylcholinessterol carrier proteinsCholesterol metabolismEicosapentaenoic acid-enriched phosphatidylcholineHepatic steatosisNonalcoholic fatty liver disease

Identifiers

PMID28012135
OpenAlexW2563944914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.