Evidence map›Paper›PMID 28012119›Full record

Observational studyInternational journal of clinical pharmacy2017

Antibiotic treatment of women with uncomplicated cystitis before and after allowing pharmacist-supply of trimethoprim.

Natalie J Gauld, Irene S L Zeng, Rosemary B Ikram, Mark G Thomas, Stephen A Buetow

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of clinical pharmacy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Pharmacist Prescriptive Authority: Lessons from Idaho.Pharmacy (Basel, Switzerland) · 2020
    Article
  12. Article
  13. Article
  14. Review
  15. Regulating pharmacist services: Achieving a full scope of practice.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Natalie J GauldNatalie Gauld Ltd, PO Box 9349, Newmarket, Auckland, 1149, New Zealand. n.gauld@auckland.ac.nz.ORCID http://orcid.org/0000-0003-0366-0357
Irene S L ZengDepartment of Statistics, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland, 1142, New Zealand.
Rosemary B IkramIndependent Consultant, Christchurch, New Zealand.
Mark G ThomasDepartment of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland, 1142, New Zealand.
Stephen A BuetowDepartment of General Practice and Primary Health Care, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland, 1142, New Zealand.
University of Auckland · NZChristchurch Clinical Studies Trust · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background In 2012, New Zealand reclassified trimethoprim to allow specially trained pharmacists to supply it without a prescription to women with symptoms suggesting uncomplicated cystitis, under strict criteria for supply. Objective To assess how this policy change allowing pharmacist supply of trimethoprim affected overall antibiotic supply. Setting Randomly selected community pharmacies throughout New Zealand. Methods Data were collected in pharmacies before the implementation ('baseline') and 1 year later ('post-implementation'). Pharmacy staff recorded prescription and nonprescription supplies for treatment or prevention of suspected urinary tract infections. Women with a prescription for treatment or prevention of presumed urinary tract infection or purchasing a non-prescription medicine for this purpose were invited to self-complete a questionnaire. National prescribing data were extracted for trimethoprim, nitrofurantoin and norfloxacin. Main outcome measure Antibiotic use in women with UTIs from dispensed prescriptions (baseline and post-implementation) and pharmacist-supplied trimethoprim (post-implementation), particularly focusing on women aged 16-65 years with an antibiotic for presumed cystitis without complicating features. Results Baseline data were provided by 139 pharmacies, 120 of which provided post-implementation data. In women with presumed cystitis without complicating features, prescriptions before and after the implementation were primarily for trimethoprim. Overall antibiotic use, and use of second-line agents did not increase post-implementation. Pharmacist-supplies of trimethoprim were modest nearly 1 year after the service started. Conclusion Supply of trimethoprim by specially trained pharmacists working within strict criteria for supply appeared to have little overall effect on antibiotic use. Further research on patient outcomes, resistance and changes over time is recommended.

Indexed as

Professional RoleAnti-Bacterial AgentsAnti-Infective Agents, UrinaryCystitisFemaleHumansPharmacistsPilot ProjectsSurveys and QuestionnairesTreatment OutcomeTrimethoprimAnti-Bacterial AgentsAnti-Infective Agents, UrinaryTrimethoprimAnti-bacterialsAntimicrobial stewardshipGeneral practiceNew ZealandNon-prescription drugsPharmacyTrimethoprim

Identifiers

PMID28012119
OpenAlexW2561451803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.