ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2017
Three-dimensional micro-computed tomography analysis for spinal instability after lumbar facetectomy in the rat.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 14 citations in OpenAlex.
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- Establishment and research progress of animal models for intervertebral disc degeneration.Open life sciences · 2026Article
- The Effects of Different Coronal Plane Angulations during Foraminoplasty on Lumbar Stability: A Combined Clinical and Biomechanical Study.Clinics in orthopedic surgery · 2025Article
- Development of a rat model with lumbar vertebral endplate lesion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Experimental Rat Model of Bony Defects in the Facet Joint Maintained with Bone Wax for the Study of Spinal Pain.Journal of pain research · 2022Article
- Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions.Bone research · 2021Review
- Role of Curcuminoids and Tricalcium Phosphate Ceramic in Rat Spinal Fusion.Tissue engineering. Part C, Methods · 2020Article
- Stress enhances gait disturbance induced by lumbar disc degeneration in rat.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
purposeIntervertebral disc degeneration is thought to contribute to low back pain. However, the pathophysiological mechanisms remain controversial. In a previous study, we developed an animal model that showed delayed gait disturbance after lumbar facetectomy in the rat. We believe that this gait disturbance was caused by low back pain, although the mechanisms of this gait abnormality remain unknown. The purpose of this study was to evaluate structural changes of the lumbar spine after facetectomy in the rat utilizing three-dimensional micro-computed tomography (3DμCT) compared to histology.
methodsThirty male SD rats were divided into three groups. In the Sham group (n = 13), only exposure of bilateral facet joints at the L4-5 level was performed. In the Experimental group (n = 13), complete resection of bilateral L4-5 facet joints was achieved. Naïve rats (n = 4) were used for controls. At 7-week postoperative, 3DµCT and histological analyses were performed.
resultsOn 3DµCT images, increased disc height and endplate irregularities at the L4-5 segment and decreased disc height at adjacent segments were observed in the Experimental group. Histological scores were also higher in the Experimental group than the Sham Group.
conclusionsDegenerative changes were observed at the facetectomy level. These may correspond with the previously reported delayed gait disturbance after facetectomy. This animal model may be useful to create mechanically induced disc degeneration without direct tissue damage to the disc.
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