SynthesisPediatric nephrology (Berlin, Germany)2017
Primary non-surgical management of unilateral ureteropelvic junction obstruction in children: a systematic review.
Synthesis in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Hepatocyte growth factor blocks epithelial-mesenchymal transition and fibrosis of ureteral epithelial cells in UPJO.BMC pediatrics · 2026Article
- Laparoscopic pyeloplasty in infants with ureteropelvic junction obstruction managed with the enhanced recovery after surgery approach: a single-center experience.BMC urology · 2025Article
- Intermittent Ureteropelvic Junction Obstruction Can Mimic Abdominal Migraine: A Case Report and Review of the Literature.Clinical case reports · 2025Article
- Retrocaval ureter and right ureteropelvic junction obstruction: a case report and literature review.Frontiers in medicine · 2025Article
- Swiss Consensus on Prenatal and Early Postnatal Urinary Tract Dilation: Practical Approach and When to Refer.Children (Basel, Switzerland) · 2024Review
- Article
- Fetal uropathies: pre- and postnatal imaging, management and follow-up.Pediatric radiology · 2023Article
- Understanding ureteropelvic junction obstruction: how far have we come?Frontiers in urology · 2023Review
- The role of Plasma Renin Activity in prenatally diagnosed non-obstructed hydronephrosis at risk for surgery-an observational study.Journal of nephrology · 2022Observational
- Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis.The Journal of international medical research · 2021Article
- Treatment of infants with ureteropelvic junction obstruction: findings from the PURSUIT network.International urology and nephrology · 2021Article
- The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney.Frontiers in cell and developmental biology · 2021Review
- Urine Biomarkers Combined With Ultrasound for the Diagnosis of Obstruction in Pediatric Hydronephrosis.Frontiers in pediatrics · 2021Article
- Management of antenatal hydronephrosis.Pediatric nephrology (Berlin, Germany) · 2020Review
- Selective Detection of Nano-Sized Diagnostic Markers Using Au-ZnO Nanorod-Based Surface-Enhanced Raman Spectroscopy (SERS) in Ureteral Obstruction Models.International journal of nanomedicine · 2020Article
- Symptomatology and Clinic of Hydronephrosis Associated With Uretero Pelvic Junction Anomalies.Frontiers in pediatrics · 2020Review
- Diuretic Enhanced Ultrasonography in the Diagnosis of Pyeloureteral Obstruction.Medicina (Kaunas, Lithuania) · 2019Article
- Surgical decision-making in infants with suspected UPJ obstruction: stakeholder perspectives.Journal of pediatric urology · 2019Article
- A Predictive Model of Postnatal Surgical Intervention in Children With Prenatally Detected Congenital Anomalies of the Kidney and Urinary Tract.Frontiers in pediatrics · 2019Article
- Clinical Outcome of Children With Antenatally Diagnosed Hydronephrosis.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ureteropelvic junction obstruction (UPJO) is the most common obstructive uropathy and its optimal management remains controversial. However, there is a current trend towards non-surgical management. We aimed to determine the effects of the non-surgical management in children with unilateral UPJO. For a systematic review, we searched MEDLINE, EMBASE, CENTRAL, clinical trials registries, and selected conference proceedings for eligible studies. Any type of study reporting the outcomes renal function, secondary surgical intervention, drainage pattern or hydronephrosis of non-surgical management in children with unilateral UPJO was included. Data from 20 studies were extracted and evaluated by two independent authors. The pooled prevalence was 21% for split renal function deterioration, 27.9% for secondary surgical intervention, 3.2% for progressive hydronephrosis, and 82.2% for improved drainage pattern. Not all patients with surgical intervention regained split renal function from enrolment. Renal imaging methods did not strongly correlate with each other. Many studies had to be excluded because of a lack of detection of an obstruction or mixed populations with bilateral UPJO or other uropathies. The variable definitions of UPJO, different criteria for surgical intervention, incongruity of management protocols, and the imprecise reporting of outcomes were limiting factors in the comparability of the results, leading to heterogeneity in meta-analyses. Although the available evidence cannot recommend or refute the current non-surgical management, the systematic review clarifies aspects of the ongoing controversy by providing realistic estimates for non-surgical management in children with unilateral UPJO. Additionally, it reveals unclear potential risks, particularly for long-term outcomes, which were rarely reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.