Evidence map›Paper›PMID 28011883›Full record

ArticlePhysiological genomics2017

Single cell transcriptomic profiling of mouse pancreatic progenitors.

Diana E Stanescu, Reynold Yu, Kyoung-Jae Won, Doris A Stoffers

Open access · greenAbstract read
In one paragraph

Article in Physiological genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Diana E StanescuDivision of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-2410-8951
Reynold YuInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Kyoung-Jae WonInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Doris A StoffersInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; stoffers@mail.med.upenn.edu.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

Career Development Program in Pediatric Diabetes Research (K12) at CHOPK12DK094723 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WILLI, STEVEN M · 2011 to 2020
$3.6M
Formation of endocrine pancreas progenitorsU01DK089540 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI STOFFERS, DORIS A · 2010 to 2014
$3.0M
Formation and maturation of endocrine pancreas progenitorsR01DK105689 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GANNON, MAUREEN A, STOFFERS, DORIS A · 2016 to 2019
$2.2M
Role of the RNA-binding, polyC-binding proteins in pancreatic beta cellsR01DK122039 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI STOFFERS, DORIS A · 2019 to 2022
$1.8M
Tracing transcriptomic changes to uncover unknown roles of TZDsR01DK106027 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEALE, PATRICK, WON, KYOUNG JAE · 2015 to 2019
$1.7M
NIDDK NIH HHS K12 DK094723NIDDK NIH HHS R01 DK105689NIDDK NIH HHS R01 DK106027NIDDK NIH HHS R01 DK122039NIDDK NIH HHS U01 DK089540
6 · The paper itself

Abstract

The heterogeneity of the developing pancreatic epithelium and low abundance of endocrine progenitors limit the information derived from traditional expression studies. To identify genes that characterize early developmental tissues composed of multiple progenitor lineages, we applied single-cell RNA-Seq to embryonic day (e)13.5 mouse pancreata and performed integrative analysis with single cell data from mature pancreas. We identified subpopulations expressing macrophage or endothelial markers and new pancreatic progenitor markers. We also identified potential α-cell precursors expressing glucagon (

Indexed as

Gene Expression ProfilingSingle-Cell AnalysisAmino Acid Transport Systems, NeutralAnimalsCell DifferentiationCluster AnalysisEmbryo, MammalianEmbryonic DevelopmentIslets of LangerhansMiceModels, BiologicalPancreasStem CellsAmino Acid Transport Systems, NeutralSNAT5 protein, mousealpha cell markerpancreas developmentsingle cell RNA-Seq

Identifiers

PMID28011883
PMCPMC5336600
OpenAlexW2561912783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.