ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2016
Patient-specific modeling of left ventricular electromechanics as a driver for haemodynamic analysis.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A three-dimensional printed model in preoperative consent for ventricular septal defect repair.Journal of cardiothoracic surgery · 2021Trial
- Accurate Reconstruction of Right Heart Shape and Motion From Cine-MRI for Image-Driven Computational Hemodynamics.International journal for numerical methods in biomedical engineering · 2025Article
- A comprehensive mathematical model for cardiac perfusion.Scientific reports · 2023Article
- The role of three-dimensional model in preoperative communication before partial nephrectomy and postoperative management.Asia-Pacific journal of oncology nursing · 2023Article
- Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference configuration.Journal of computational physics · 2022Article
- An Integrated Workflow for Building Digital Twins of Cardiac Electromechanics-A Multi-Fidelity Approach for Personalising Active Mechanics.Mathematics (Basel, Switzerland) · 2022Article
- A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation.Computer methods in applied mechanics and engineering · 2021Article
- Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function.International journal for numerical methods in biomedical engineering · 2021Article
- Data integration for the numerical simulation of cardiac electrophysiology.Pacing and clinical electrophysiology : PACE · 2021Review
- Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering.Micromachines · 2021Review
- Personalization of electro-mechanical models of the pressure-overloaded left ventricle: fitting of Windkessel-type afterload models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium.Journal of biomechanics · 2020Article
- A publicly available virtual cohort of four-chamber heart meshes for cardiac electro-mechanics simulations.PloS one · 2020Article
- Optimization Framework for Patient-Specific Cardiac Modeling.Cardiovascular engineering and technology · 2019Article
- Virtual downsizing for decision support in mitral valve repair.International journal of computer assisted radiology and surgery · 2019Article
- Assessment of wall stresses and mechanical heart power in the left ventricle: Finite element modeling versus Laplace analysis.International journal for numerical methods in biomedical engineering · 2018Article
- Towards a Computational Framework for Modeling the Impact of Aortic Coarctations Upon Left Ventricular Load.Frontiers in physiology · 2018Article
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Authors and funding
10 authors.
Funding
Abstract
aimsModels of blood flow in the left ventricle (LV) and aorta are an important tool for analysing the interplay between LV deformation and flow patterns. Typically, image-based kinematic models describing endocardial motion are used as an input to blood flow simulations. While such models are suitable for analysing the hemodynamic status quo, they are limited in predicting the response to interventions that alter afterload conditions. Mechano-fluidic models using biophysically detailed electromechanical (EM) models have the potential to overcome this limitation, but are more costly to build and compute. We report our recent advancements in developing an automated workflow for the creation of such CFD ready kinematic models to serve as drivers of blood flow simulations. METHODS AND
resultsEM models of the LV and aortic root were created for four pediatric patients treated for either aortic coarctation or aortic valve disease. Using MRI, ECG and invasive pressure recordings, anatomy as well as electrophysiological, mechanical and circulatory model components were personalized.
resultsThe implemented modeling pipeline was highly automated and allowed model construction and execution of simulations of a patient's heartbeat within 1 day. All models reproduced clinical data with acceptable accuracy.
conclusionUsing the developed modeling workflow, the use of EM LV models as driver of fluid flow simulations is becoming feasible. While EM models are costly to construct, they constitute an important and nontrivial step towards fully coupled electro-mechano-fluidic (EMF) models and show promise as a tool for predicting the response to interventions which affect afterload conditions.
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