Evidence map›Paper›PMID 28011641›Full record

ArticleThe Journal of biological chemistry2017

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

Padmaja Mehta-D'souza, Arkadiusz G Klopocki, Vaheh Oganesyan, Simon Terzyan, Timothy Mather, Zhenhai Li, Sumith R Panicker, Cheng Zhu, Rodger P McEver

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. The Role of Glycans in Human Immunity-A Sweet Code.Molecules (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Cancers · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. What is the Sugar Code?Chembiochem : a European journal of chemical biology · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 5 countries.

Padmaja Mehta-D'souzaFrom the Cardiovascular Biology Research Program and.
Arkadiusz G KlopockiFrom the Cardiovascular Biology Research Program and.
Vaheh OganesyanFrom the Cardiovascular Biology Research Program and.
Simon TerzyanCrystallography Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104.
Timothy MatherFrom the Cardiovascular Biology Research Program and.
Zhenhai Lithe Coulter Department of Biomedical Engineering.
Sumith R PanickerFrom the Cardiovascular Biology Research Program and.
Cheng Zhuthe Coulter Department of Biomedical Engineering.
Rodger P McEverFrom the Cardiovascular Biology Research Program and rodger-mcever@omrf.org.ORCID 0000-0001-5343-2622
Cardiovascular Institute Hospital · JPGeorgia Institute of Technology · USOklahoma Medical Research Foundation · US

Funding

Protein-glycan Interactions in the Vascular SystemP01HL085607 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CUMMINGS, RICHARD D, MCEVER, RODGER PAUL · 2006 to 2015
$16.8M
Visualizing Single Integrin Conformational Changes on Living CellsR01AI044902 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2000 to 2016
$5.8M
Signal-dependent neutrophil adhesion to vascular surfacesR01HL034363 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI MCEVER, RODGER PAUL · 1985 to 2017
$3.9M
Single-platelet analysis of mechano-reception by GPIb alphaR01HL132019 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2016 to 2024
$3.8M
CYTOPLASMIC REGULATION OF P-SELECTIN/PSGL-1 INTERACTIONSR37HL034363 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MCEVER, RODGER PAUL · 1998 to 2007
$3.3M
Mechanical Regulation of Selectin-Ligand Binding KineticsR01AI077343 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI MCEVER, RODGER PAUL, ZHU, CHENG · 2010 to 2014
$2.5M
Mechanical regulation of selectin-ligand binding kineticsR56AI077343 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2008 to 2008
$151k
NHLBI NIH HHS P01 HL085607NHLBI NIH HHS R01 HL034363NHLBI NIH HHS R01 HL132019NHLBI NIH HHS R37 HL034363NIAID NIH HHS R01 AI044902NIAID NIH HHS R01 AI077343NIAID NIH HHS R56 AI077343
6 · The paper itself

Abstract

Selectin interactions with fucosylated glycan ligands mediate leukocyte rolling in the vasculature under shear forces. Crystal structures of P- and E-selectin suggest a two-state model in which ligand binding to the lectin domain closes loop 83-89 around the Ca

Indexed as

AnimalsCHO CellsCricetinaeCricetulusCrystallography, X-RayGlutamic AcidHumansL-SelectinMembrane GlycoproteinsPolysaccharidesProtein ConformationGlutamic AcidL-SelectinMembrane GlycoproteinsPolysaccharidesP-selectin ligand proteincarbohydrate-binding proteincell adhesionendothelial cellglycobiologyinflammationleukocyte

Identifiers

PMID28011641
PMCPMC5313117
OpenAlexW2565348719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.