Evidence map›Paper›PMID 28011634›Full record

ArticleThe Journal of biological chemistry2017

Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from

Vladimir M Levdikov, Elena Blagova, Vicki L Young, Boris R Belitsky, Andrey Lebedev, Abraham L Sonenshein, Anthony J Wilkinson

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  4. Suppressor analysis inFrontiers in microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Vladimir M LevdikovFrom the Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.
Elena BlagovaFrom the Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.
Vicki L YoungFrom the Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.
Boris R Belitskythe Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, and.
Andrey Lebedevthe STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, Oxfordshire OX11 0QX, United Kingdom.
Abraham L Sonensheinthe Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, and.
Anthony J WilkinsonFrom the Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom, tony.wilkinson@york.ac.uk.ORCID 0000-0003-4577-9479
University of York · GBTufts University · USRutherford Appleton Laboratory · GB

Funding

ISOLATION OF EARLY SPORULATION GENESR01GM042219 · NIGMS · TUFTS UNIVERSITY BOSTON · PI SONENSHEIN, ABRAHAM LINCOLN · 1989 to 2015
$5.8M
Biotechnology and Biological Sciences Research Council BBS/B/1213XNIGMS NIH HHS R01 GM042219Wellcome TrustWellcome Trust 082829/Z/07/Z
6 · The paper itself

Abstract

CodY is a branched-chain amino acid (BCAA) and GTP sensor and a global regulator of transcription in low G + C Gram-positive bacteria. It controls the expression of over 100 genes and operons, principally by repressing during growth genes whose products are required for adaptations to nutrient limitation. However, the mechanism by which BCAA binding regulates transcriptional changes is not clear. It is known that CodY consists of a GAF (c

Indexed as

Amino Acids, Branched-ChainBacillus subtilisBacterial ProteinsCrystallography, X-RayLigandsProtein BindingProtein ConformationAmino Acids, Branched-ChainBacterial ProteinsLigandsBacillusDNA-binding proteinprotein structuretranscription repressorX-ray crystallography

Identifiers

PMID28011634
PMCPMC5314169
OpenAlexW2562739910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.