ArticleThe EMBO journal2017
Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans.
Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Canonical and noncanonical Hippo signaling in C. elegans.Genetics · 2026Article
- The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters.Nature communications · 2025Article
- Germ granule compartments coordinate specialized small RNA production.Nature communications · 2024Article
- A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing.Cell reports · 2022Article
- CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA.BMC biology · 2020Article
- Spatial confinement of receptor activity by tyrosine phosphatase during directional cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis.The Korean journal of parasitology · 2020Article
- The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine ofGenetics · 2019Article
- Spectrin-based membrane skeleton supports ciliogenesis.PLoS biology · 2019Article
- The USTC co-opts an ancient machinery to drive piRNA transcription inGenes & development · 2019Article
- Suppression of YAP by DDP disrupts colon tumor progression.Oncology reports · 2018Article
- Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans.The EMBO journal · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precise positioning of cells is crucial for metazoan development. Despite immense progress in the elucidation of the attractive cues of cell migration, the repulsive mechanisms that prevent the formation of secondary leading edges remain less investigated. Here, we demonstrate that Caenorhabditis elegans Hippo kinases promote cell migration along the anterior-posterior body axis via the inhibition of dorsal-ventral (DV) migration. Ectopic DV polarization was also demonstrated in gain-of-function mutant animals for C. elegans RhoG MIG-2. We identified serine 139 of MIG-2 as a novel conserved Hippo kinase phosphorylation site and demonstrated that purified Hippo kinases directly phosphorylate MIG-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.