Evidence map›Paper›PMID 28011461›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Antitumor Activity of RXDX-105 in Multiple Cancer Types with

Gang G Li, Romel Somwar, James Joseph, Roger S Smith, Takuo Hayashi, Leenus Martin, Aleksandra Franovic, Anni Schairer, Eric Martin, Gregory J Riely and 8 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Cancers · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Novel Preclinical Patient-Derived Lung Cancer Models Reveal Inhibition of HER3 and MTOR Signaling as Therapeutic Strategies for NRG1 Fusion-Positive Cancers.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2021
    Article
  16. The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with OncogenicClinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  17. Review
  18. Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations.Annals of oncology : official journal of the European Society for Medical Oncology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Gang G LiIgnyta, Inc., San Diego, California. gli@ignyta.com drilona@mskcc.org.
Romel SomwarMemorial Sloan Kettering Cancer Center, New York, New York.
James JosephIgnyta, Inc., San Diego, California.
Roger S SmithMemorial Sloan Kettering Cancer Center, New York, New York.
Takuo HayashiMemorial Sloan Kettering Cancer Center, New York, New York.
Leenus MartinIgnyta, Inc., San Diego, California.
Aleksandra FranovicIgnyta, Inc., San Diego, California.
Anni SchairerIgnyta, Inc., San Diego, California.
Eric MartinIgnyta, Inc., San Diego, California.
Gregory J RielyMemorial Sloan Kettering Cancer Center, New York, New York.
Jason HarrisIgnyta, Inc., San Diego, California.
Shunqi YanIgnyta, Inc., San Diego, California.
Ge WeiIgnyta, Inc., San Diego, California.
Jennifer W OliverIgnyta, Inc., San Diego, California.
Rupal PatelIgnyta, Inc., San Diego, California.
Pratik MultaniIgnyta, Inc., San Diego, California.
Marc LadanyiMemorial Sloan Kettering Cancer Center, New York, New York.
Alexander DrilonMemorial Sloan Kettering Cancer Center, New York, New York. gli@ignyta.com drilona@mskcc.org.
Kettering University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
NCATS NIH HHS UL1 TR002384NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell Line, TumorCell ProliferationCell SurvivalGene RearrangementHumansMiceMutationNeoplasm ProteinsNeoplasmsProtein Kinase InhibitorsProto-Oncogene Proteins c-retSignal TransductionXenograft Model Antitumor AssaysNeoplasm ProteinsProtein Kinase InhibitorsProto-Oncogene Proteins c-retRET protein, human

Identifiers

PMID28011461
PMCPMC5477238
OpenAlexW2561621356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.