Evidence map›Paper›PMID 28011387›Full record

Trial reportContemporary clinical trials2017

The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease.

Vanessa Grubbs, Faviola Garcia, Bonnie L Jue, Eric Vittinghoff, Mark Ryder, David Lovett, Jacqueline Carrillo, Steven Offenbacher, Peter Ganz, Kirsten Bibbins-Domingo and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. [A Meta-analysis of the effect of non-surgical periodontal therapy on inflammatory factors in patients with chronic kidney disease and periodontitis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Vanessa GrubbsDivision of Nephrology, University of California, San Francisco, 1001 Potrero Avenue, Building 100, Room 342, San Francisco, CA 94110, USA. Electronic address: vanessa.grubbs@ucsf.edu.
Faviola GarciaDivision of Nephrology, University of California, San Francisco, 1001 Potrero Avenue, Building 100, Room 342, San Francisco, CA 94110, USA. Electronic address: faviola.garcia@ucsf.edu.
Bonnie L JueDivision of Oral Epidemiology & Dental Public Health, Department of Preventive & Restorative Dental Sciences, University of California, San Francisco, 3333 California Street, Ste 495, San Francisco, CA 94118, USA. Electronic address: bonnie.jue@ucsf.edu.
Eric VittinghoffDivision of Epidemiology & Biostatistics, University of California, San Francisco, 550 16th Street, San Francisco, CA 94158, USA. Electronic address: Eric.Vittinghoff@ucsf.edu.
Mark RyderDivision of Periodontology, Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, 533 Parnassus Avenue, UC Hall, 94143, San Francisco, CA, USA. Electronic address: Mark.Ryder@ucsf.edu.
David LovettDivision of Nephrology, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA. Electronic address: David.Lovett@ucsf.edu.
Jacqueline CarrilloDivision of General Internal Medicine, University of California, San Francisco, 1001 Potrero Avenue, Building 10, San Francisco, CA 94110, USA. Electronic address: jacqueline.carrillo@ucsf.edu.
Steven OffenbacherDepartment of Periodontology, Center for Oral and Systemic Diseases, UNC School of Dentistry, Koury Health Sciences Building, 385 S. Columbia Street, Room 3501F, Chapel Hill, NC 27599, USA. Electronic address: steven_offenbacher@unc.edu.
Peter GanzDivision of Cardiology, University of California, San Francisco, 1001 Potrero Avenue, Building 5, San Francisco, CA 94110, USA. Electronic address: Peter.Ganz@ucsf.edu.
Kirsten Bibbins-DomingoDivision of General Internal Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA 94158, USA. Electronic address: Kirsten.bibbins-domingo@ucsf.edu.
Neil R PoweDepartment of Medicine, University of California, San Francisco, 1001 Potrero Avenue, Building 5, San Francisco, CA 94110, USA. Electronic address: neil.powe@ucsf.edu.
University of California, San Francisco · USSan Francisco General Hospital · USSan Francisco VA Medical Center · USUniversity of North Carolina Health Care · US

Funding

The Role of Periodontal Disease in Chronic Kidney Disease ProgressionK23DK093710 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRUBBS, VANESSA · 2012 to 2016
$1.0M
NIDDK NIH HHS K23 DK093710
6 · The paper itself

Abstract

introductionChronic kidney disease (CKD) remains a prevalent public health problem that disproportionately affects minorities and the poor, despite intense efforts targeting traditional risk factors. Periodontal diseases are common bacterial plaque-induced inflammatory conditions that can respond to treatment and have been implicated as a CKD risk factor. However there is limited evidence that treatment of periodontal disease slows the progression of CKD. METHODS/

designWe describe the protocol of the Kidney and Periodontal Disease (KAPD) study, a 12-month un-blinded, randomized, controlled pilot trial with two intent-to-treat treatment arms: 1. immediate intensive non-surgical periodontal treatment or 2. rescue treatment with delayed intensive treatment. The goals of this pilot study are to test the feasibility of conducting a larger trial in an ethnically and racially diverse, underserved population (mostly poor and/or low literacy) with both CKD and significant periodontal disease to determine the effect of intensive periodontal treatment on renal and inflammatory biomarkers over a 12-month period.

resultsTo date, KAPD has identified 634 potentially eligible patients who were invited to in-person screening. Of the 83 (13.1%) of potentially eligible patients who attended in-person screening, 51 (61.4%) were eligible for participation and 46 enrolled in the study. The mean age of participants is 59.2years (range 34 to 73). Twenty of the participants (43.5%) are Black and 22 (47.8%) are Hispanic. DISCUSSION: Results from the KAPD study will provide needed preliminary evidence of the effectiveness of non-surgical periodontal treatment to slow CKD progression and inform the design future clinical research trials.

Indexed as

AdultAlbuminuriaCreatinineDisease ProgressionFemaleHumansLipocalin-2MaleMiddle AgedPeriodontal DiseasesPeriodontal IndexPeriodontitisPilot ProjectsRenal Insufficiency, ChronicVulnerable PopulationsYoung AdultCreatinineLCN2 protein, humanLipocalin-2(max 6) chronic kidney diseaseNon-surgical periodontal disease treatmentPeriodontal diseasePeriodontitis, oral health

Identifiers

PMID28011387
PMCPMC6237429
OpenAlexW2561349658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.