Evidence map›Paper›PMID 28011330›Full record

ArticleJournal of hepatology2017

Current progress in immunotherapy of hepatocellular carcinoma.

Martin F Sprinzl, Peter R Galle

3 registry-linked trialsAbstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Journal of hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03895970 phase2completednot on this mapstarted 2019, after this paper: background citation

Lenvatinib Combined Pembrolizumab as a Second-line Treatment in Advanced Hepatobiliary Tumors: a Single-center, Single-arm, Non-randomized Clinical Study

TypeinterventionalSponsorPeking Union Medical College HospitalRan2019 to 2021Enrolled32ConditionsLiver Neoplasm Malignant Primary, Cholangiocarcinoma, Combinational Immunotherapy, BiomarkerArmsLenvatinib plus Pembrolizumab
NCT04010071 phase2unknown statusnot on this mapstarted 2020, after this paper: background citation

Axitinib Plus Toripalimab as Second-line Treatment in Hepatobiliary Malignant Tumors: a Single-arm, Non-randomized, Single-center Phase II Trial

TypeinterventionalSponsorPeking Union Medical College HospitalRan2020 to 2024Enrolled60ConditionsHepatobiliary Neoplasm, Liver Neoplasm, Biliary Tract NeoplasmsArmsaxitinib plus toripalimab
NCT05048017 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Regorafenib Combined With PD-1 Inhibitor Therapy for Second-line Treatment of Hepatocellular Carcinoma: A Single Arm, Nonrandomized, Single Center Clinical Study

TypeinterventionalSponsorPeking Union Medical College HospitalRan2021 to 2025Enrolled20ConditionsHepatocellular Carcinoma, Regorafenib, PD-1 InhibitorArmsRegorafenib, PD-1 inhibitor
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Sorafenib alone vs. sorafenib plus GEMOX as 1British journal of cancer · 2019
    Trial
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  4. Review
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  6. Nanotechnology for the Diagnosis and Treatment of Liver Cancer.International journal of nanomedicine · 2024
    Review
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Martin F SprinzlDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Peter R GalleDepartment of Internal Medicine I, University Medical Center of the Johannes Gutenberg University Mainz, Germany. Electronic address: galle@uni-mainz.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHumansImmunotherapyCheckpoint inhibitorsImmunotherapyLiver cancerTherapy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.