Evidence map›Paper›PMID 28011041›Full record

ArticleJournal of comparative pathology2017

Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type.

K S Im, J H Kim, A J Graef, I Cornax, D M Seelig, M G O'Sullivan, R C Kovi, J F Modiano

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of comparative pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

K S ImAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
J H KimAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
A J GraefAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
I CornaxAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
D M SeeligAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
M G O'SullivanAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
R C KoviAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
J F ModianoAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, USA. Electronic address: modiano@umn.edu.
University of Minnesota Medical Center · USUniversity of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
NCI NIH HHS P30 CA077598
6 · The paper itself

Abstract

The pathogenesis of canine T-cell lymphoma remains incompletely understood, partly because there are no well-established in-vivo models to study these malignancies. For this study, we generated a patient-derived tumour xenograft (PDTX) from a 10-year-old neutered male golden retriever dog with enteropathy-associated intestinal T-cell lymphoma, large cell type. One of two female, 15-week-old beige/nude/XID mice developed a visible tumour 7 weeks after sections of tumour material from the spleen were surgically implanted. The histological appearance, immunophenotype and clonal antigen receptor rearrangements of the tumour from the recipient mouse showed that it was derived from the primary canine tumour. Our results indicate that immunodeficient mice are receptive hosts to develop in-vivo PDTX models to study the pathogenesis and management of canine T-cell lymphomas.

Indexed as

Disease Models, AnimalDog DiseasesAnimalsDogsEnteropathy-Associated T-Cell LymphomaFemaleHeterograftsMaleMiceMice, Nudedogenteropathy-associated T-cell lymphomaimmunodeficient mouse modelpatient-derived tumour xenograft

Identifiers

PMID28011041
PMCPMC5292073
OpenAlexW2561722296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.