Evidence map›Paper›PMID 28010188›Full record

ReviewRNA biology2017

The in vivo genetic toolkit for studying expression and functions of Drosophila melanogaster microRNAs.

Hina Iftikhar, Janna N Schultzhaus, Chloe J Bennett, Ginger E Carney

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. The Role of miRNAs inGenetics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hina Iftikhara Department of Biology , Texas A&M University , TX , USA.
Janna N Schultzhausa Department of Biology , Texas A&M University , TX , USA.
Chloe J Bennetta Department of Biology , Texas A&M University , TX , USA.
Ginger E Carneya Department of Biology , Texas A&M University , TX , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the initial reports that a group of small RNAs, now known as microRNAs (miRNAs), regulates gene expression without being translated into proteins, there has been an explosion of studies on these important expression modulators. Drosophila melanogaster has proven to be one of the most amenable animal models for investigations of miRNA biogenesis and gene regulatory activities. Here, we highlight the publicly available genetic tools and strategies for in vivo functional studies of miRNA activity in D. melanogaster. By coupling genetic approaches using available strain libraries with technologies for miRNA expression analysis and target and pathway prediction, researchers' ability to test functional activities of miRNAs in vivo is now greatly enhanced. We also comment on the tools that need to be developed to aid in comprehensive evaluation of Drosophila miRNA activities that impact traits of interest.

Indexed as

Gene Expression RegulationAnimalsComputational BiologyDrosophila melanogasterGene Regulatory NetworksGenetic Association StudiesGenomicsInternetMicroRNAsMutationRNA InterferenceSoftwareMicroRNAsDrosophila melanogastergeneticsin vivomicroRNAtools

Identifiers

PMID28010188
PMCPMC5324739

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.