Evidence map›Paper›PMID 28010062›Full record

ArticleJournal of the American Chemical Society2017

Covalent Modulators of the Vacuolar ATPase.

Ying-Chu Chen, Keriann M Backus, Maria Merkulova, Christina Yang, Dennis Brown, Benjamin F Cravatt, Chao Zhang

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Endosomal Mechanisms in Heart Failure Pathophysiology.Current heart failure reports · 2025
    Review
  2. Article
  3. Role of Senataxin in Amyotrophic Lateral Sclerosis.Journal of molecular neuroscience : MN · 2023
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Electron-Deficient Alkynes as Powerful Tools against Root-Knot NematodeJournal of agricultural and food chemistry · 2020
    Article
  10. Article
  11. Covalent targeting of the vacuolar HNature chemical biology · 2019
    Article
  12. Reactive-cysteine profiling for drug discovery.Current opinion in chemical biology · 2019
    Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ying-Chu Chen
Keriann M BackusDepartment of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States.
Maria MerkulovaMGH Center for Systems Biology, Program in Membrane Biology & Division of Nephrology, Richard B. Simches Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School , Boston, Massachusetts 02114, United States.
Christina Yang
Dennis BrownMGH Center for Systems Biology, Program in Membrane Biology & Division of Nephrology, Richard B. Simches Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School , Boston, Massachusetts 02114, United States.
Benjamin F CravattDepartment of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States.ORCID 0000-0001-5330-3492
Harvard University · USScripps Research Institute · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Regulation of proton pump trafficking in kidneyR37DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2008 to 2017
$4.0M
Targeting an immune kinase to purge KSHV latent infectionR01DE026003 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, CASEY, ZHANG, CHAO · 2016 to 2020
$3.4M
Chemical Approaches for Activity-Based ProteomicsR37CA087660 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F · 2009 to 2018
$3.1M
CHEMICAL APPROACHES FOR ACTIVITY BASED PROTEOMICSR01CA087660 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F · 2000 to 2008
$2.8M
NCI NIH HHS R01 CA087660NCI NIH HHS R37 CA087660NIDCR NIH HHS R01 DE026003NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R37 DK042956
6 · The paper itself

Abstract

The vacuolar H

Indexed as

Models, BiologicalMolecular StructureSmall Molecule LibrariesVacuolar Proton-Translocating ATPasesSmall Molecule LibrariesVacuolar Proton-Translocating ATPases

Identifiers

PMID28010062
PMCPMC5274637
OpenAlexW2566055968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.