Evidence map›Paper›PMID 28009853›Full record

ArticleMolecules (Basel, Switzerland)2016

Pharmacological Properties of Riparin IV in Models of Pain and Inflammation.

Olívia Azevêdo Nascimento, Renan Fernandes do Espírito-Santo, Luíza Carolina França Opretzka, José Maria Barbosa-Filho, Stanley Juan Chavez Gutierrez, Cristiane Flora Villarreal, Milena Botelho Pereira Soares

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Cleomin Exerts Acute Antinociceptive Effects in Mice via GABAPharmaceuticals (Basel, Switzerland) · 2023
    Article
  3. 5-International journal of molecular sciences · 2021
    Article
  4. (E)-2-Cyano-3-(1International journal of molecular sciences · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olívia Azevêdo NascimentoFaculdade de Farmácia, Universidade Federal da Bahia, 40170-290 Salvador, BA, Brazil. olivia_azevedo@hotmail.com.
Renan Fernandes do Espírito-SantoCentro de Pesquisas Gonçalo Moniz, FIOCRUZ, 40296-710 Salvador, BA, Brazil. r.fernandes88@hotmail.com.
Luíza Carolina França OpretzkaFaculdade de Farmácia, Universidade Federal da Bahia, 40170-290 Salvador, BA, Brazil. luizacfo@ufba.br.
José Maria Barbosa-FilhoLaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, 58051-900 João Pessoa, PB, Brazil. barbosa.ufpb@gmail.com.
Stanley Juan Chavez GutierrezDepartamento de Bioquímica e Farmacologia, Universidade Federal do Piauí, 64049-550 Teresina, PI, Brazil. stanleychavez@ufpi.edu.br.
Cristiane Flora VillarrealFaculdade de Farmácia, Universidade Federal da Bahia, 40170-290 Salvador, BA, Brazil. cfv@ufba.br.
Milena Botelho Pereira SoaresCentro de Pesquisas Gonçalo Moniz, FIOCRUZ, 40296-710 Salvador, BA, Brazil. milena@bahia.fiocruz.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Riparins, natural alkaloids of the alkamide group, can be synthesized by simple methods, enhancing their potential application in pharmaceutical development. Here, the pharmacological properties of riparins were investigated in in vitro and in vivo assays of pain and inflammation in Swiss mice. Inflammatory mediators were measured by radioimmunoassay and Real-Time PCR. Riparins I, II, III and IV (1.56-100 mg/kg; ip) produced dose-related antinociceptive effects in the formalin test, exhibiting ED

Indexed as

AlkaloidsAnalgesicsAnimalsAnti-Inflammatory AgentsBenzamidesCyclooxygenase 2DinoprostoneEdemaFreund's AdjuvantGene ExpressionInflammationInterleukin-10MaleMicePainPain ManagementAlkaloidsAnalgesicsAnti-Inflammatory AgentsBenzamidesCyclooxygenase 2DinoprostoneFreund's AdjuvantIL10 protein, mouseInterleukin-10Ptgs2 protein, mouseTumor Necrosis Factor-alphaanti-inflammatoryantinociceptioncytokinesPGE2riparins

Identifiers

PMID28009853
PMCPMC6274570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.