ReviewMolecules (Basel, Switzerland)2016
Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals.
Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Advances in the clinical applications of sodium thiosulphate.Annals of medicine · 2026Review
- Mitochondrial responses to anoxia-reoxygenation exposure in crucian carp (Carassius carassius).The Journal of experimental biology · 2026Article
- Antimicrobial Efficacy of Phyto-L, Thiosulfonate fromVeterinary sciences · 2023Article
- Review
- Reactive Oxygen, Nitrogen, and Sulfur Species (RONSS) as a Metabolic Cluster for Signaling and Biostimulation of Plants: An Overview.Plants (Basel, Switzerland) · 2022Review
- Sulfur Administration in Fe-S Cluster Homeostasis.Antioxidants (Basel, Switzerland) · 2021Review
- Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms.International journal of molecular sciences · 2021Review
- Investigating Different Forms of Hydrogen Sulfide in Cerebrospinal Fluid of Various Neurological Disorders.Metabolites · 2021Article
- Evaluation of Cysteine Metabolism in the Rat Liver and Kidney Following Intravenous Cocaine Administration and Abstinence.Antioxidants (Basel, Switzerland) · 2021Article
- Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease.Toxins · 2020Review
- Tissue-dependent variation of hydrogen sulfide homeostasis in anoxic freshwater turtles.The Journal of experimental biology · 2019Article
- Inorganic Polysulfides and Related Reactive Sulfur–Selenium Species from the Perspective of Chemistry.Molecules (Basel, Switzerland) · 2019Review
- Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells.Antioxidants (Basel, Switzerland) · 2019Article
- Chemical Biology of HChemical reviews · 2018Review
- Atomic Sulfur: An Element for Adaptation to an Oxidative Environment.Molecules (Basel, Switzerland) · 2017Article
- Cysteine persulfides and polysulfides produced by exchange reactions with HRedox biology · 2017Article
- Hydrogen sulfide, endoplasmic reticulum stress and alcohol mediated neurotoxicity.Brain research bulletin · 2017Review
- Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur.Molecules (Basel, Switzerland) · 2017Article
- Sulphurous Mineral Waters: New Applications for Health.Evidence-based complementary and alternative medicine : eCAM · 2017Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It was in the 1950s that the term polysulfide or persulfide was introduced in biological studies. The unfamiliar term "sulfane sulfur" sometimes appeared in papers published in the 1970s, and was defined in the review article by Westley in 1983. In the article, sulfane sulfur is described as sulfur atoms that are covalently bound only with sulfur atoms, and as this explanation was somewhat difficult to comprehend, it was not generally accepted. Thus, in the early 1990s, we redefined these sulfur species as "bound sulfur", which easily converts to hydrogen sulfide on reduction with a thiol reducing agent. In other words, bound sulfur refers to a sulfur atom that exists in a zero to divalent form (0 to -2). The first part of this review focuses on the fluorescent derivatization HPLC method-which we developed for measurement of bound sulfur-and explains the distribution of bound sulfur and the hydrogen sulfide-producing ability of various tissues, as clarified by this method. Next, we discuss diverse physiological functions and involvement of polysulfide, a typical type of bound sulfur, in the redox regulation system. Additionally, we also address its possible physiological role in the central nervous system, based on its action of scavenging reactive carbonyl compounds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.