Evidence map›Paper›PMID 28009827›Full record

ArticleInternational journal of molecular sciences2016

Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen-Antioxidant Mutual Prodrugs.

Zaman Ashraf, Alamgeer, Raqiqatur Rasool, Mubashir Hassan, Haseeb Ahsan, Samina Afzal, Khurram Afzal, Hongsik Cho, Song Ja Kim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Phytophenols as Promoieties for Prodrug Design.Current drug discovery technologies · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Zaman AshrafDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, Pakistan. mzchem@yahoo.com.
AlamgeerDepartment of Pharmacology, Faculty of Pharmacy University of Sargodha, Sargodha 40100, Pakistan. alam_yuchi@yahoo.com.
Raqiqatur RasoolDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, Pakistan. raqiqa_chem@yahoo.com.
Mubashir HassanDepartment of Biology, College of Natural Sciences, Kongju National University, Gongju 314701, Korea. mubashirhassan_gcul@yahoo.com.
Haseeb AhsanDepartment of Pharmacology, Faculty of Pharmacy University of Sargodha, Sargodha 40100, Pakistan. haseebahsan110@yahoo.com.
Samina AfzalFaculty of Pharmacy, BahauddinZakria University, Multan 60800, Pakistan. samina.afzal@bzu.edu.pk.
Khurram AfzalFaculty of Pharmacy, BahauddinZakria University, Multan 60800, Pakistan. khurram.afzal@bzu.edu.pk.
Hongsik ChoDepartment of Orthopaedic Surgery & Biomedical Engineering, University of Tennessee Health Science Center-Campbell Clinic, Memphis, TN 38104, USA. hcho4@uthsc.edu.
Song Ja KimDepartment of Biology, College of Natural Sciences, Kongju National University, Gongju 314701, Korea. ksj85@kongju.ac.kr.
Allama Iqbal Open University · PKBahauddin Zakariya University · PKKongju National University · KRUniversity of Sargodha · PKUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dexibuprofen-antioxidant conjugates were synthesized with the aim to reduce its gastrointestinal effects. The esters analogs of dexibuprofen

Indexed as

Molecular Docking SimulationAnimalsBlood PlateletsCyclooxygenase 2Cyclooxygenase 2 InhibitorsFemaleIbuprofenIntestinal MucosaMaleMiceProdrugsProtein BindingCyclooxygenase 2Cyclooxygenase 2 InhibitorsdexibuprofenIbuprofenProdrugsantioxidantsdexibuprofenin vitro hydrolysismolecular dynamics simulationmutual prodrugsnonsteroidal anti-inflammatory drugs (NSAIDs)pharmacological activity

Identifiers

PMID28009827
PMCPMC5187951
OpenAlexW2566827042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.