Evidence map›Paper›PMID 28009821›Full record

ReviewViruses2016

Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity.

Glen R Nemerow, Phoebe L Stewart

Abstract readReview
In one paragraph

Review in Viruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Construction and application of adenoviral vectors.Molecular therapy. Nucleic acids · 2023
    Review
  2. Review
  3. Review
  4. Review
  5. Genome Analyses of Ten New Ape Adenoviruses with Similarity to HumanInternational journal of molecular sciences · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Antiviral Activities of Human Host Defense Peptides.Current medicinal chemistry · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Glen R NemerowDepartment of Immunology and Microbial Science the Scripps Research Institute, La Jolla, CA 92037, USA. gnemerow@scripps.edu.
Phoebe L StewartDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106, USA. pls47@case.edu.

Funding

AV INTEGRINS AND ADENOVIRUS INTERNALIZATIONR01HL054352 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMEROW, GLEN R · 1995 to 2016
$7.5M
Mechanisms of adenovirus neutralizationR01AI107960 · NIAID · EMORY UNIVERSITY · PI SHAYAKHMETOV, DMITRY, STEWART, PHOEBE L · 2014 to 2024
$6.5M
Mechanochemical studies of adenovirus cell entryR21AI112714 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMEROW, GLEN R · 2015 to 2016
$423k
NHLBI NIH HHS R01 HL054352NIAID NIH HHS R01 AI107960NIAID NIH HHS R21 AI112714
6 · The paper itself

Abstract

Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules.

Indexed as

Immunity, InnateVirus UncoatingAdenoviruses, HumanHost-Pathogen InteractionsHumansIntegrinsIntegrinsadenovirusadenovirus receptorsAFMantibodycapsid disassemblycryoelectron microscopycysteine proteasedefensinsdyneinhexonintegrinsmicrotubulesneutralizationnuclear porenuclear porinspenton baseprotein VIts1

Identifiers

PMID28009821
PMCPMC5192398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.