Trial reportAnnals of surgery2017
Safety and Feasibility of Minimally Invasive Inguinal Lymph Node Dissection in Patients With Melanoma (SAFE-MILND): Report of a Prospective Multi-institutional Trial.
Trial report in Annals of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01500304 (Feasibility and Safety of Minimally Invasive Inguinal Lymph Node Dissection in Patients With Melanoma), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Safety of Minimally Invasive Inguinal Lymph Node Dissection in Patients With Melanoma
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Inguinal lymph node metastases from rectal adenocarcinoma: a systematic review.Techniques in coloproctology · 2023Pooled it
- Conventional Versus Videoscopic Inguinal Lymphadenectomy in Surgical Oncology: A Retrospective Observational Cohort Study.Annals of surgical oncology · 2026Observational
- Current surgical management for melanoma.The Journal of dermatology · 2024Article
- Oncological outcome of videoscopic groin dissection for lymph node metastasis from melanoma.Surgical endoscopy · 2021Article
- Safety and feasibility of single-incision radical vulvectomy: a novel approach for the treatment of vulvar cancer.Annals of translational medicine · 2021Article
- Minimally invasive inguinal lymph node dissection: initial experience and reproducibility in a limited resource setting-with technique video.Surgical endoscopy · 2020Article
- Laparoscopically assisted ilio-inguinal lymph node dissection versus inguinal lymph node dissection in melanoma.Melanoma management · 2020Article
- Successful laparoscopic trans-peritoneal repair of an incisional inguinal hernia, resulting from deep lymph node dissection for melanoma: A case report.International journal of surgery case reports · 2020Article
- Completing the Dissection in Melanoma: Increasing Decision Precision.Annals of surgical oncology · 2018Article
- Lymph node retrieval rates in melanoma: a quality assessment parameter.Current oncology (Toronto, Ont.) · 2017Article
- Laparoscopic skill assessment of practicing surgeons prior to enrollment in a surgical trial of a new laparoscopic procedure.Surgical endoscopy · 2017Article
- A surgical perspective report on melanoma management.Melanoma management · 2017Review
- Lymph node dissection for melanoma: where do we stand?Melanoma management · 2017Review
- The Role of Surgery for Melanoma in an Era of Effective Systemic Therapy.Current oncology reports · 2017Review
- Morbidity After Inguinal Lymph Node Dissections: It Is Time for a Change.Annals of surgical oncology · 2017Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMinimally invasive inguinal lymph node dissection (MILND) is a novel approach to inguinal lymphadenectomy. SAFE-MILND (NCT01500304) is a multicenter, phase I/II clinical trial evaluating the safety and feasibility of MILND for patients with melanoma in a group of surgeons newly adopting the procedure.
methodsTwelve melanoma surgeons from 10 institutions without any previous MILND experience, enrolled patients into a prospective study after completing specialized training including didactic lectures, participating in a hands-on cadaveric laboratory, and being provided an instructional DVD of the procedure. Complications and adverse postoperative events were graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events Version 4.0.
resultsEighty-seven patients underwent a MILND. Seventy-seven cases (88.5%) were completed via a minimally invasive approach. The median total inguinal lymph nodes pathologically examined (SLN + MILND) was 12.0 (interquartile range 8.0, 14.0). Overall, 71% of patients suffered an adverse event (AE); the majority of these were grades 1 and 2, with 26% of patients experiencing a grade 3 AE. No grade 4 or 5 AEs were observed.
conclusionsAfter a structured training program, high-volume melanoma surgeons adopted a novel surgical technique with a lymph node retrieval rate that met or exceeded current oncologic guidelines and published benchmarks, and a favorable morbidity profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.