ArticleBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis2017
Relation of coagulation factor XI with incident coronary heart disease and stroke: the Cardiovascular Health Study.
Article in Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Factor XI levels and the risk of cardiovascular events: a systematic review and meta-analysis of case-control and cohort studies.Research and practice in thrombosis and haemostasis · 2025Article
- Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS.Circulation · 2025Article
- Clinical Markers and Diagnostics for Diagnosing Cerebral Infarction.CNS & neurological disorders drug targets · 2025Review
- Factor XI and Atrial Fibrillation: A Mismatched Pairing?European cardiology · 2025Article
- Levels of procoagulant factors and peak thrombin generation in relation to dementia risk in older adults: The Cardiovascular Health Study.Thrombosis research · 2024Article
- Coagulation factor with potential for the treatment of heart failure.Clinical and translational medicine · 2022Article
- Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure.Science (New York, N.Y.) · 2022Article
- Nanowired dual-electrodes surface to monitor cerebral ischemia by current-volt measurements.3 Biotech · 2021Article
- Associations of coagulation factor X and XI with incident acute coronary syndrome and stroke: A nested case-control study.Journal of thrombosis and haemostasis : JTH · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
: The role of coagulation factor XI (FXI) in the cause of arterial thrombotic events remains uncertain. We examined the association of FXI with incident coronary heart disease (CHD), ischemic stroke, and hemorrhagic stroke. Data were from 3394 adults (mean age: 74.5 years) enrolled in the Cardiovascular Health Study who had FXI antigen from plasma samples drawn in 1992-1993 and were followed for cardiovascular events until 30 June 2013. Approximately 63% of participants were women and 17% were black. FXI levels were higher in blacks and women, showed positive associations with high-density lipoprotein and total cholesterol, BMI and diabetes, and negative associations with age and alcohol intake. During median follow-up of 13 years, we identified 1232 incident CHD, 473 ischemic stroke, and 84 hemorrhagic stroke events. In multivariable Cox models adjusted for traditional cardiovascular disease risk factors, the hazard ratio per one SD (32.2 mg/dl) increment of FXI was 1.02 (95% confidence interval: 0.96-1.08) for CHD; 0.94 (0.85-1.04) for ischemic stroke, and 0.85 (0.65-1.10) for hemorrhagic stroke. In this prospective cohort of elderly adults, there was no statistically significant association of higher FXI levels with incident CHD and stroke.
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