Evidence map›Paper›PMID 28009481›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017

Renal Allograft Survival in Nonhuman Primates Infused With Donor Antigen-Pulsed Autologous Regulatory Dendritic Cells.

M B Ezzelarab, D Raich-Regue, L Lu, A F Zahorchak, A Perez-Gutierrez, A Humar, M Wijkstrom, M Minervini, R W Wiseman, D K C Cooper and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

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  9. Donor-derived regulatory dendritic cell infusion results in host cell cross-dressing and T cell subset changes in prospective living donor liver transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
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  19. Regulatory dendritic cells for human organ transplantation.Transplantation reviews (Orlando, Fla.) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

M B EzzelarabDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
D Raich-RegueDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
L LuDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
A F ZahorchakDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
A Perez-GutierrezDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
A HumarDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
M WijkstromDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
M MinerviniDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
R W WisemanWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.
D K C CooperDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
A E MorelliDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
A W ThomsonDepartment of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
University of Pittsburgh · USUniversity of Wisconsin–Madison · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
RHESUS MONKEY DENDRITIC CELLS FOR TRANSPLANT TOLERANCEU01AI051698 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2002 to 2011
$4.9M
HL Exosomes as paracrine signal mediators in cardiac allograft rejectionR01HL130191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORELLI, ADRIAN E. · 2016 to 2019
$1.5M
NCI NIH HHS P30 CA047904NHLBI NIH HHS R01 HL130191NIAID NIH HHS U01 AI051698
6 · The paper itself

Abstract

Systemic administration of autologous regulatory dendritic cells (DCreg; unpulsed or pulsed with donor antigen [Ag]), prolongs allograft survival and promotes transplant tolerance in rodents. Here, we demonstrate that nonhuman primate (NHP) monocyte-derived DCreg preloaded with cell membrane vesicles from allogeneic peripheral blood mononuclear cells induce T cell hyporesponsiveness to donor alloantigen (alloAg) in vitro. These donor alloAg-pulsed autologous DCreg (1.4-3.6 × 10

Indexed as

Kidney TransplantationTissue DonorsAnimalsDendritic CellsGraft SurvivalIsoantigensKidney Failure, ChronicLeukocytes, MononuclearMacaca mulattaMaleT-LymphocytesTransplantation, HomologousTransplantation ToleranceIsoantigensanimal models: nonhuman primatebasic (laboratory) research/sciencedendritic cellfusion proteins and monoclonal antibodies: belataceptimmunobiologyimmunosuppressantimmunosuppression/immune modulationkidney transplantation/nephrologymechanistic target of rapamycin (mTOR)T cell biologytranslational research/science

Identifiers

PMID28009481
PMCPMC5444942
OpenAlexW2561134207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.