Evidence map›Paper›PMID 28009354›Full record

ArticleCell death and differentiation2017

RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts.

Steffi Gieseler-Halbach, Stefan Meltendorf, Mandy Pierau, Soenke Weinert, Florian H Heidel, Thomas Fischer, Juliane Handschuh, Ruediger C Braun-Dullaeus, Martin Schrappe, Jonathan A Lindquist and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cell death and differentiation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. YB-1 activating cascades as potential targets in KRAS-mutated tumors.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Review
  7. Article
  8. The Pleiotropic Effects of YBX1 on HTLV-1 Transcription.International journal of molecular sciences · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Steffi Gieseler-HalbachDepartment of Experimental Pediatrics, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Stefan MeltendorfDepartment of Experimental Pediatrics, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Mandy PierauDepartment of Experimental Pediatrics, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Soenke WeinertDepartment of Internal Medicine, Division of Cardiology and Angiology, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Florian H HeidelDivision of Hematology and Oncology, Department of Internal Medicine, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Thomas FischerDivision of Hematology and Oncology, Department of Internal Medicine, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Juliane HandschuhDepartment of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg 39118, Germany.
Ruediger C Braun-DullaeusDepartment of Internal Medicine, Division of Cardiology and Angiology, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Martin SchrappeDepartment of Pediatrics, University Medical Centre Schleswig-Holstein, Kiel, Germany.
Jonathan A LindquistClinic of Nephrology, Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg 39120, Germany.
Peter R MertensClinic of Nephrology, Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg 39120, Germany.
Ulrich ThomasDepartment of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg 39118, Germany.
Monika C Brunner-WeinzierlDepartment of Experimental Pediatrics, University Hospital, Otto-von-Guericke University, Magdeburg 39120, Germany.
Otto-von-Guericke University Magdeburg · DELeibniz Institute for Neurobiology · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deregulated proliferation is key to tumor progression. Although unrestricted proliferation of solid tumor cells correlates with the cold-shock protein Y-box (YB)-binding protein-1 accumulation in the nuclei, little is known about its expression and function in hematopoietic malignancies, such as T-cell acute lymphoblastic leukemia (T-ALL). Here we show that YB-1 protein is highly enriched in the nuclei of activated T cells and malignant human T-ALL cell lines but not in resting T cells. YB-1 S

Indexed as

AdolescentAdultAgedBenzopyransCD4-Positive T-LymphocytesCell ProliferationCells, CulturedChildChild, PreschoolEnterotoxinsFemaleHumansJurkat CellsMaleMiddle AgedMonosaccharidesBenzopyransEnterotoxinsMonosaccharidesProtein Kinase CProto-Oncogene Proteins c-aktRibosomal Protein S6 Kinases, 90-kDaSL0101Y-Box-Binding Protein 1

Identifiers

PMID28009354
PMCPMC5299718
OpenAlexW2564822919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.