Evidence map›Paper›PMID 28009294›Full record

ArticleCell reports2016

Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex.

Josef Turecek, Skyler L Jackman, Wade G Regehr

Abstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The cerebellar deep nuclei: a patch for rate codes?Frontiers in neural circuits · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Rate versus synchrony codes for cerebellar control of motor behavior.bioRxiv : the preprint server for biology · 2023
    Article
  16. Article
  17. A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. The Cerebellar Cortex.Annual review of neuroscience · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Josef TurecekDepartment of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA.
Skyler L JackmanDepartment of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA.
Wade G RegehrDepartment of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA. Electronic address: wade_regehr@hms.harvard.edu.

Funding

Mechanisms and Functions of Synapses and CircuitsR35NS097284 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2017 to 2024
$7.5M
Short-Term Synaptic Plasticity in the CNSR01NS032405 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI REGEHR, WADE G · 1995 to 2016
$4.8M
Retrograde Signaling by Endogenous CannabinoidsR01NS044396 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI REGEHR, WADE G · 2002 to 2006
$1.6M
Regulation of Synchrony and Input Layer Excitability by Purkinje Cell CollateralsR01NS092707 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2015 to 2016
$647k
NINDS NIH HHS R01 NS032405NINDS NIH HHS R01 NS044396NINDS NIH HHS R01 NS092707NINDS NIH HHS R35 NS097284
6 · The paper itself

Abstract

The output of the cerebellar cortex is conveyed to the deep cerebellar nuclei (DCN) by Purkinje cells (PCs). Here, we characterize the properties of the PC-DCN synapse in juvenile and adult mice and find that prolonged high-frequency stimulation leads to steady-state responses that become increasingly frequency independent within the physiological firing range of PCs in older animals, resulting in a linear relationship between charge transfer and activation frequency. We used a low-affinity antagonist to show that GABA

Indexed as

AgingAnimalsCerebellar CortexCerebellar NucleiMicePurkinje CellsReceptors, GABA-ASynapsesSynaptic TransmissionReceptors, GABA-Acerebellumdeep cerebellar nucleuspresynapticPurkinje cellsreceptor saturationrecovery from depressionshort-term facilitationTPMPA

Identifiers

PMID28009294
PMCPMC5870134

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.