Evidence map›Paper›PMID 28009286›Full record

ArticleCell reports2016

The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells.

Florencia Marcucci, Veronica Murcia-Belmonte, Qing Wang, Yaiza Coca, Susana Ferreiro-Galve, Takaaki Kuwajima, Sania Khalid, M Elizabeth Ross, Carol Mason, Eloisa Herrera

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. EphA4 Mediates EphrinB1-Dependent Adhesion in Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Frontiers in cell and developmental biology · 2025
    Review
  9. Development of the Binocular Circuit.Annual review of neuroscience · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Florencia MarcucciDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Veronica Murcia-BelmonteInstituto de Neurociencias de Alicante (Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández), 03550 Sant Joan d'Alacant, Spain.
Qing WangDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Yaiza CocaInstituto de Neurociencias de Alicante (Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández), 03550 Sant Joan d'Alacant, Spain.
Susana Ferreiro-GalveInstituto de Neurociencias de Alicante (Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández), 03550 Sant Joan d'Alacant, Spain.
Takaaki KuwajimaDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Sania KhalidDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
M Elizabeth RossCenter for Neurogenetics, Feil Family Brain & Mind Research Institute, Weill Cornell Medical College, New York, NY 10021, USA.
Carol MasonDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: cam4@columbia.edu.
Eloisa HerreraInstituto de Neurociencias de Alicante (Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández), 03550 Sant Joan d'Alacant, Spain. Electronic address: e.herrera@umh.es.
Columbia University · USConsejo Superior de Investigaciones Científicas · ESCornell University · USInstituto de Neurociencias · ES

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
The Regulation of MGE Proliferation and Cortical Interneuron Fate DeterminationP01NS048120 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSS, MARGARET ELIZABETH · 2006 to 2015
$12.9M
The Role of Zic Genes in Patterning the Binocular ProjectionR01EY015290 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MASON, CAROL A. · 2004 to 2023
$7.6M
GROWTH AND GUIDANCE OF RETINAL AXONSR01EY012736 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MASON, CAROL A. · 1999 to 2017
$6.4M
Vision Sciences Training GrantT32EY013933 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Carol A. Mason, CAROL M TROY · 2001 to 2026
$5.3M
NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY012736NEI NIH HHS R01 EY015290NEI NIH HHS T32 EY013933NINDS NIH HHS P01 NS048120
6 · The paper itself

Abstract

The retina of lower vertebrates grows continuously by integrating new neurons generated from progenitors in the ciliary margin zone (CMZ). Whether the mammalian CMZ provides the neural retina with retinal cells is controversial. Live imaging of embryonic retina expressing eGFP in the CMZ shows that cells migrate laterally from the CMZ to the neural retina where differentiated retinal ganglion cells (RGCs) reside. Because Cyclin D2, a cell-cycle regulator, is enriched in ventral CMZ, we analyzed Cyclin D2

Indexed as

AnimalsCell DifferentiationCell ProliferationCiliaCyclin D2HumansMammalsMiceMice, KnockoutNeurogenesisRetinaRetinal Ganglion CellsCyclin D2binocular visionciliary margin zonecontralateral RGCsCyclin D2ipsilateral RGCsneurogenesisretinaretinal progenitors

Identifiers

PMID28009286
PMCPMC5234854
OpenAlexW2563622315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.